Human FGF-4 Active Protein – Cat# MBS695869

FGF-4 Human Active Protein

Name: FGF-4 Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS695869
Price: 180 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695869

FGF-4 is a heparin binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

FGF-4, Active Protein

Full Product Name

Human FGF-4

Product Gene Name

FGF-4 active protein

Product Synonym Names

Recombinant Human FGF-4

Sequence

GRGGAAAPT APNGTLEAE LERRWESLV ALSLARLPV AAQPKEAAV QSGAGDYLL GIKRLRRLY CNVGIGFHL QALPDGRIG GAHADTRDS LLELSPVER GVVSIFGVA SRFFVAMSS KGKLYGSPF FTDECTFKE ILLPNNYNA YESYKYPGM FIALSKNGK TKKGNRVSP TMKVTHFLP RL

Host

E Coli

Species Reactivity

Species Reactivity: Human
Cross Reactivity: Mouse, Rat

Purity/Purification

Above 95% as determined by SDS-PAGE Analysis.

Preparation and Storage

At -20 degree C

Molecular Weight

12,237 Da

OMIM

164980

3D Structure

ModBase 3D Structure for P08620

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is <= 0.5 ng/ml, corresponding to a specific activity of >= 2 x 106 units/mg.

Cell Type

Stem Cells

Product Categories/Family for FGF-4 active protein

Stem Cell Research; Angiogenesis; Proliferation and Cell Cycle

Other Notes

Small volumes of FGF-4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FGF-4 purchase

MBS695869 is an active protein targeting FGF-4. Also known as Human FGF-4. Reactive in Species Reactivity: Human
Cross Reactivity: Mouse, Rat. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF-4. It may not necessarily be applicable to this product.

NCBI GI #

122750

NCBI GeneID

2249

NCBI Accession #

P08620.1

UniProt Primary Accession #

P08620

UniProt Secondary Accession #

B7U994

UniProt Related Accession #

P08620; AAB21430

NCBI Official Full Name

Fibroblast growth factor 4

NCBI Official Synonym Full Names

fibroblast growth factor 4

NCBI Official Symbol

FGF4

NCBI Official Synonym Symbols

HST; KFGF; HST-1; HSTF1; K-FGF; HBGF-4

UniProt Protein Name

Fibroblast growth factor 4

UniProt Synonym Protein Names

Heparin secretory-transforming protein 1; HST; HST-1; HSTF-1; Heparin-binding growth factor 4; HBGF-4; Transforming protein KS3

Protein Family

Fibroblast growth factor

UniProt Gene Name

FGF4

UniProt Synonym Gene Names

HST; HSTF1; KS3; FGF-4; HST; HST-1; HSTF-1; HBGF-4

UniProt Entry Name

FGF4_HUMAN

NCBI Protein Information

fibroblast growth factor 4; FGF-4; HSTF-1; oncogene HST; kaposi sarcoma oncogene; transforming protein KS3; heparin-binding growth factor 4; heparin secretory transforming protein 1; heparin secretory-transforming protein 1; fibroblast growth factor 4 splice isoform; human stomach cancer, transforming factor from FGF-related oncogene

NCBI Summary for FGF-4

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]

UniProt Comments for FGF-4

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.

Research Articles on FGF-4

1. Data show that the interaction between Artd1 and Sox2 is crucial for the first steps of the reprogramming process and that early expression of Fgf4 is an essential component for the successful generation of iPSCs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FGF-4 active protein

Reference Product	PubMed Publications
SHH active protein	>78 publications with FGF-4 and SHH
SOX2 active protein	>69 publications with FGF-4 and SOX2
FGFR2 active protein	>52 publications with FGF-4 and FGFR2
FGFR1 active protein	>38 publications with FGF-4 and FGFR1
CTNNB1 active protein	>17 publications with FGF-4 and CTNNB1
FGFR3 active protein	>17 publications with FGF-4 and FGFR3
FGFR4 active protein	>17 publications with FGF-4 and FGFR4
MSX1 active protein	>12 publications with FGF-4 and MSX1
LEF1 active protein	>11 publications with FGF-4 and LEF1
GREM1 active protein	>5 publications with FGF-4 and GREM1

Pathways associated with FGF-4 active protein

Products by Pathway	Pathway Diagram
Activated Point Mutants Of FGFR2 Pathway antibodies	Activated Point Mutants Of FGFR2 Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies	Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Downstream Signal Transduction Pathway antibodies	Downstream Signal Transduction Pathway Diagram
Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies	Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
Downstream Signaling Of Activated FGFR Pathway antibodies	Downstream Signaling Of Activated FGFR Pathway Diagram
FGFR Ligand Binding And Activation Pathway antibodies	FGFR Ligand Binding And Activation Pathway Diagram

Diseases associated with FGF-4 active protein

Disease Name	Pubmed Publications
Skin Diseases Antibodies	>39 publications with FGF-4 and Skin Diseases
Breast Neoplasms Antibodies	>39 publications with FGF-4 and Breast Neoplasms
Disease Models, Animal Antibodies	>25 publications with FGF-4 and Disease Models, Animal
Cardiovascular Diseases Antibodies	>24 publications with FGF-4 and Cardiovascular Diseases
Neovascularization, Pathologic Antibodies	>19 publications with FGF-4 and Neovascularization, Pathologic
Nervous System Diseases Antibodies	>17 publications with FGF-4 and Nervous System Diseases
Brain Diseases Antibodies	>14 publications with FGF-4 and Brain Diseases
Necrosis Antibodies	>9 publications with FGF-4 and Necrosis
Abnormalities, Drug-Induced Antibodies	>7 publications with FGF-4 and Abnormalities, Drug-Induced
Liver Diseases Antibodies	>7 publications with FGF-4 and Liver Diseases

Organs/Tissues associated with FGF-4 active protein

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>138 publications with FGF-4 and Embryonic Tissue
Testis Antibodies	>11 publications with FGF-4 and Testis