Human BMP-6 Active Protein – Cat# MBS695912

BMP-6 Human Active Protein

Name: BMP-6 Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS695912
Price: 180 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695912

TGF-beta family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

BMP-6, Active Protein

Full Product Name

Recombinant Human BMP-6

Product Gene Name

BMP-6 active protein

Product Synonym Names

Recombinant Human BMP-6

Sequence

VSSASDYNS SELKTACRK HELYVSFQD LGWQDWIIA PKGYAANYC DGECSFPLN AHMNATNHA IVQTLVHLM NPEYVPKPC CAPTKLNAI SVLYFDDNS NVILKKYRN MVVRACGCH

Host

HEK293 cells

Species Reactivity

Species Reactivity: Human
Cross Reactivity: Mouse

Form/Format

Sterile filtered through a 0.2 micron filter. Lyophilized from 10mM Tris, pH 9.0.

Purity/Purification

> = 95% as determined by SDS-PAGE Analysis.

Preparation and Storage

At -20 degree C

Molecular Weight

57,226 Da

OMIM

112266

3D Structure

ModBase 3D Structure for P22004

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 ug/ml.

Protein Content

Verified by UV Spectroscopy and/or SDS-PAGE gel.

Endotoxin

Endotoxin level is < 0.1 ng/ug of protein <1 EU/ug).

Reconstitution

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1 % BSA) and store in working aliquots at -20 degree C to -80 degree C.

Product Categories/Family for BMP-6 active protein

Stem Cell Research; Apoptosis; Angiogenesis; Bone Biology; Proliferation and Cell Cycle

Other Notes

Small volumes of BMP-6 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMP-6 purchase

MBS695912 is an active protein targeting BMP-6. Also known as Recombinant Human BMP-6. Reactive in Species Reactivity: Human
Cross Reactivity: Mouse. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for BMP-6. It may not necessarily be applicable to this product.

NCBI GI #

115076

NCBI GeneID

654

NCBI Accession #

P22004.1

UniProt Primary Accession #

P22004

UniProt Secondary Accession #

Q5TCP3

UniProt Related Accession #

P22004

NCBI Official Full Name

Bone morphogenetic protein 6

NCBI Official Synonym Full Names

bone morphogenetic protein 6

NCBI Official Symbol

BMP6

NCBI Official Synonym Symbols

VGR; VGR1

UniProt Protein Name

Bone morphogenetic protein 6

UniProt Synonym Protein Names

VG-1-related protein; VG-1-R; VGR-1

Protein Family

Bone morphogenetic protein

UniProt Gene Name

BMP6

UniProt Synonym Gene Names

VGR; BMP-6; VG-1-R; VGR-1

UniProt Entry Name

BMP6_HUMAN

NCBI Protein Information

bone morphogenetic protein 6; BMP-6; VGR-1; VG-1-R; VG-1-related protein; Vg1-related sequence; vegetal-related (TGFB related) cytokine; vegetal related growth factor (TGFB-related)

NCBI Summary for BMP-6

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity. [provided by RefSeq, Jul 2008]

UniProt Comments for BMP-6

BMP6: Induces cartilage and bone formation. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 6p24-p23

Cellular Component: extracellular space; cytoplasm

Molecular Function: growth factor activity; protein heterodimerization activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: cellular iron ion homeostasis; response to glucocorticoid stimulus; regulation of apoptosis; BMP signaling pathway; response to magnesium ion; positive regulation of endothelial cell differentiation; positive regulation of aldosterone biosynthetic process; male genitalia development; kidney development; inflammatory response; response to iron ion; skeletal development; endochondral ossification; response to retinoic acid; positive regulation of bone mineralization; osteoblast differentiation; positive regulation of osteoblast differentiation; positive regulation of chondrocyte differentiation; positive regulation of protein secretion; eye development; regulation of MAPKKK cascade; cartilage development; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; response to activity; positive regulation of neuron differentiation; positive regulation of epithelial cell proliferation; growth

Research Articles on BMP-6

1. these data highlight a therapeutically innovative role for BMP6 by providing a means to enhance the amount of myogenic lineage derived brown fat.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BMP-6 active protein

Reference Product	PubMed Publications
BMPR2 active protein	>58 publications with BMP-6 and BMPR2
BMPR1A active protein	>31 publications with BMP-6 and BMPR1A
SMAD5 active protein	>27 publications with BMP-6 and SMAD5
BMPR1B active protein	>15 publications with BMP-6 and BMPR1B
ACVR2A active protein	>4 publications with BMP-6 and ACVR2A
NOG active protein	>2 publications with BMP-6 and NOG

Pathways associated with BMP-6 active protein

Products by Pathway	Pathway Diagram
BMP Receptor Signaling Pathway antibodies	BMP Receptor Signaling Pathway Diagram
Endochondral Ossification Pathway antibodies	Endochondral Ossification Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram
Id Signaling Pathway antibodies	Id Signaling Pathway Diagram
Ovarian Steroidogenesis Pathway antibodies	Ovarian Steroidogenesis Pathway Diagram
Ovarian Steroidogenesis Pathway antibodies	Ovarian Steroidogenesis Pathway Diagram
TGF-beta Signaling Pathway antibodies	TGF-beta Signaling Pathway Diagram
TGF-beta Signaling Pathway antibodies	TGF-beta Signaling Pathway Diagram

Diseases associated with BMP-6 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>33 publications with BMP-6 and Inflammation
Anemia Antibodies	>32 publications with BMP-6 and Anemia
Disease Models, Animal Antibodies	>26 publications with BMP-6 and Disease Models, Animal
Hemochromatosis Antibodies	>25 publications with BMP-6 and Hemochromatosis
Liver Diseases Antibodies	>18 publications with BMP-6 and Liver Diseases
Adenocarcinoma Antibodies	>17 publications with BMP-6 and Adenocarcinoma
Fibrosis Antibodies	>13 publications with BMP-6 and Fibrosis
Necrosis Antibodies	>12 publications with BMP-6 and Necrosis
Kidney Diseases Antibodies	>12 publications with BMP-6 and Kidney Diseases
Nervous System Diseases Antibodies	>11 publications with BMP-6 and Nervous System Diseases

Organs/Tissues associated with BMP-6 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>86 publications with BMP-6 and Blood
Connective Tissue Antibodies	>44 publications with BMP-6 and Connective Tissue
Ovary Antibodies	>37 publications with BMP-6 and Ovary
Embryonic Tissue Antibodies	>32 publications with BMP-6 and Embryonic Tissue
Brain Antibodies	>31 publications with BMP-6 and Brain
Vascular Antibodies	>26 publications with BMP-6 and Vascular
Prostate Antibodies	>24 publications with BMP-6 and Prostate
Kidney Antibodies	>18 publications with BMP-6 and Kidney
Mouth Antibodies	>13 publications with BMP-6 and Mouth
Lung Antibodies	>12 publications with BMP-6 and Lung