Human BAFF Active Protein – Cat# MBS695917

BAFF Human Active Protein

Name: BAFF Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS695917
Price: 180 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695917

BAFF, a member of the TNF family of ligands, is expressed in T cells, macrophages, monocytes and dendritic cells. BAFF is involved in stimulation of B and T cell function, and is an important survival and maturation factor for peripheral B cells. BAFF signals… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

BAFF, Active Protein

Full Product Name

Human BAFF

Product Gene Name

BAFF active protein

Product Synonym Names

Recombinant Human BAFF

Sequence

AVQGPEETV TQDCLQLIA DSETPTIQK GSYTFVPWL LSFKRGSAL EEKENKILV KETGYFFIY GQVLYTDKT YAMGHLIQR KKVHVFGDE LSLVTLFRC IQNMPETLP NNSCYSAGI AKLEEGDEL QLAIPRENA QISLDGDVT FFGALKLL

Host

E Coli

Species Reactivity

Species Reactivity: Human
Cross Reactivity: Mouse

Purity/Purification

Above 95% as determined by SDS-PAGE Analysis.

Preparation and Storage

At -20 degree C

Molecular Weight

17,578 Da

OMIM

603969

3D Structure

ModBase 3D Structure for Q9Y275

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Determined by a mouse splenocyte survival assay. The expected ED50 for this effect is 0.5-2.0 ug/ml.

Cell Type

B Cells, Monocytes and Macrophages, T Cells, Dendritic Cells

Product Categories/Family for BAFF active protein

Stem Cell Research; Apoptosis; Immunology

Other Notes

Small volumes of BAFF active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BAFF purchase

MBS695917 is an active protein targeting BAFF. Also known as Human BAFF. Reactive in Species Reactivity: Human
Cross Reactivity: Mouse. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BAFF. It may not necessarily be applicable to this product.

NCBI GI #

13124573

NCBI GeneID

10673

NCBI Accession #

Q9Y275.1

UniProt Primary Accession #

Q9Y275

UniProt Secondary Accession #

Q6FHD6; Q7Z5J2; E0ADT7

UniProt Related Accession #

Q9Y275

NCBI Official Full Name

Tumor necrosis factor ligand superfamily member 13B

NCBI Official Synonym Full Names

tumor necrosis factor (ligand) superfamily, member 13b

NCBI Official Symbol

TNFSF13B

NCBI Official Synonym Symbols

DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20

UniProt Protein Name

Tumor necrosis factor ligand superfamily member 13B

UniProt Synonym Protein Names

B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1; CD_antigen: CD257Cleaved into the following 2 chains:Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form

Protein Family

Tumor necrosis factor receptor superfamily

UniProt Gene Name

TNFSF13B

UniProt Synonym Gene Names

BAFF; BLYS; TALL1; TNFSF20; ZTNF4; BLyS; TALL-1

UniProt Entry Name

TN13B_HUMAN

NCBI Protein Information

tumor necrosis factor ligand superfamily member 13B; delta BAFF; Delta4 BAFF; B-lymphocyte stimulator; B-cell-activating factor; ApoL related ligand TALL-1; TNF homolog that activates apoptosis; dendritic cell-derived TNF-like molecule; tumor necrosis factor-like protein ZTNF4; TNF and ApoL-related leukocyte expressed ligand 1; tumor necrosis factor (ligand) superfamily, member 20

NCBI Summary for BAFF

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

UniProt Comments for BAFF

BAFF: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Apoptosis; Membrane protein, integral; Cytokine

Chromosomal Location of Human Ortholog: 13q32-q34

Cellular Component: extracellular space; perinuclear region of cytoplasm; cytoplasm; plasma membrane; integral to membrane

Molecular Function: protein binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: cell proliferation; B cell costimulation; B cell homeostasis; immunoglobulin secretion; positive regulation of cell proliferation; T cell costimulation; positive regulation of germinal center formation; positive regulation of B cell proliferation; positive regulation of T cell proliferation; immune response; signal transduction

Research Articles on BAFF

1. In patients who did not develop chronic graft-versus-host disease, there is a temporal pattern of gradually decreasing BAFF levels as B cell numbers increase after myeloablative conditioning.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BAFF active protein

Reference Product	PubMed Publications
TNFRSF13C active protein	>120 publications with BAFF and TNFRSF13C
TNFRSF17 active protein	>103 publications with BAFF and TNFRSF17
TNFRSF13B active protein	>77 publications with BAFF and TNFRSF13B
IL6 active protein	>12 publications with BAFF and IL6
AICDA active protein	>6 publications with BAFF and AICDA
IFNG active protein	>2 publications with BAFF and IFNG
CD40LG active protein	>1 publications with BAFF and CD40LG

Pathways associated with BAFF active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram
Intestinal Immune Network For IgA Production Pathway antibodies	Intestinal Immune Network For IgA Production Pathway Diagram
NF-kappa B Signaling Pathway antibodies	NF-kappa B Signaling Pathway Diagram
Rheumatoid Arthritis Pathway antibodies	Rheumatoid Arthritis Pathway Diagram
Rheumatoid Arthritis Pathway antibodies	Rheumatoid Arthritis Pathway Diagram
Spinal Cord Injury Pathway antibodies	Spinal Cord Injury Pathway Diagram

Diseases associated with BAFF active protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>445 publications with BAFF and Necrosis
Inflammation Antibodies	>76 publications with BAFF and Inflammation
Nervous System Diseases Antibodies	>53 publications with BAFF and Nervous System Diseases
Kidney Diseases Antibodies	>31 publications with BAFF and Kidney Diseases
Skin Diseases Antibodies	>25 publications with BAFF and Skin Diseases
Liver Diseases Antibodies	>14 publications with BAFF and Liver Diseases
Bone Marrow Diseases Antibodies	>13 publications with BAFF and Bone Marrow Diseases
Thrombocytopenia Antibodies	>12 publications with BAFF and Thrombocytopenia
Hyperplasia Antibodies	>10 publications with BAFF and Hyperplasia
Leukopenia Antibodies	>7 publications with BAFF and Leukopenia

Organs/Tissues associated with BAFF active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>593 publications with BAFF and Blood
Bone Marrow Antibodies	>66 publications with BAFF and Bone Marrow
Lymph Node Antibodies	>44 publications with BAFF and Lymph Node
Kidney Antibodies	>36 publications with BAFF and Kidney
Skin Antibodies	>18 publications with BAFF and Skin
Vascular Antibodies	>14 publications with BAFF and Vascular
Liver Antibodies	>13 publications with BAFF and Liver
Brain Antibodies	>12 publications with BAFF and Brain
Thymus Antibodies	>8 publications with BAFF and Thymus
Pharynx Antibodies	>8 publications with BAFF and Pharynx