Human BCA-1 Active Protein – Cat# MBS695923

BCA-1 / BLC (BCA-1) Human Active Protein

Name: BCA-1 Active Protein; BCA-1 / BLC; Human; MyBioSource
Brand: MyBioSource
SKU: MBS695923
Price: 180 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695923

BCA-1/BLC, a CXC chemokine, is expressed in the liver, spleen, lymph nodes, appendix and stomach. It exerts its activities through its only receptor CXCR5. BCA-1/BLC is a potent chemoattractant for B lymphocytes and induces weak chemotactic response in T… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

BCA-1 / BLC, Active Protein

Full Product Name

Human BCA-1 / BLC (CXCL13)

Product Gene Name

BCA-1 active protein

Product Synonym Gene Name

BLC

Product Synonym Names

Recombinant Human BCA-1/BLC (CXCL13)

Sequence

VLEVYYTSL RCRCVQESS VFIPRRFID RIQILPRGN GCPRKEIIV WKKNKSIVC VDPQAEWIQ RMMEVLRKR SSSTLPVPV FKRKIP

Host

E Coli

Species Reactivity

Species Reactivity: Human
Cross Reactivity: Human, Mouse

Purity/Purification

Above 98% as determined by SDS-PAGE Analysis.

Preparation and Storage

At -20 degree C

Molecular Weight

12,664 Da

OMIM

605149

3D Structure

ModBase 3D Structure for O43927

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Determined by its ability to chemoattract human B cells using a concentration range of 1.0-10.0 ng/ml.

Cell Type

B Cells, Monocytes and Macrophages, T Cells

Product Categories/Family for BCA-1 active protein

Immunology; Chemotaxis

Other Notes

Small volumes of BCA-1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BCA-1 purchase

MBS695923 is an active protein targeting BCA-1. Also known as Human BCA-1 / BLC (CXCL13). Reactive in Species Reactivity: Human
Cross Reactivity: Human, Mouse. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BCA-1. It may not necessarily be applicable to this product.

NCBI GI #

7673945

NCBI GeneID

10563

NCBI Accession #

O43927.1

UniProt Primary Accession #

O43927

UniProt Related Accession #

O43927

NCBI Official Full Name

C-X-C motif chemokine 13

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 13

NCBI Official Symbol

CXCL13

NCBI Official Synonym Symbols

BLC; BCA1; ANGIE; BCA-1; BLR1L; ANGIE2; SCYB13

UniProt Protein Name

C-X-C motif chemokine 13

UniProt Synonym Protein Names

Angie; B cell-attracting chemokine 1; BCA-1; B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13

Protein Family

Beta carbonic anhydrase

UniProt Gene Name

CXCL13

UniProt Synonym Gene Names

BCA1; BLC; SCYB13; BCA-1

UniProt Entry Name

CXL13_HUMAN

NCBI Protein Information

C-X-C motif chemokine 13; CXC chemokine BLC; B-cell chemoattractant; B-lymphocyte chemoattractant; b lymphocyte chemoattractant; small-inducible cytokine B13; B-cell-attracting chemokine 1; b cell-attracting chemokine 1; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1); small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant)

NCBI Summary for BCA-1

B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]

UniProt Comments for BCA-1

CXCL13: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; fibroblast growth factor binding; CXCR3 chemokine receptor binding; chemokine activity; protein heterodimerization activity; CXCR5 chemokine receptor binding; CCR10 chemokine receptor binding; receptor agonist activity

Biological Process: chronic inflammatory response; lymphocyte chemotaxis across high endothelial venule; response to lipopolysaccharide; lymph node development; positive regulation of integrin activation; regulation of angiogenesis; positive regulation of cell-cell adhesion mediated by integrin; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; cell-cell signaling; regulation of humoral immune response; defense response to bacterium; germinal center formation; immune response; inflammatory response

Research Articles on BCA-1

1. CXCL13 displays antimicrobial activity against E. coli and S. aureus.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BCA-1 active protein

Reference Product	PubMed Publications
CXCR5 active protein	>185 publications with BCA-1 and CXCR5
CCL21 active protein	>121 publications with BCA-1 and CCL21
CCL19 active protein	>97 publications with BCA-1 and CCL19
CCR7 active protein	>50 publications with BCA-1 and CCR7
CXCL9 active protein	>28 publications with BCA-1 and CXCL9
CXCR3 active protein	>27 publications with BCA-1 and CXCR3
CCL20 active protein	>23 publications with BCA-1 and CCL20
CXCL11 active protein	>14 publications with BCA-1 and CXCL11
CCL25 active protein	>12 publications with BCA-1 and CCL25
CXCR1 active protein	>8 publications with BCA-1 and CXCR1

Pathways associated with BCA-1 active protein

Products by Pathway	Pathway Diagram
CXCR3-mediated Signaling Events Pathway antibodies	CXCR3-mediated Signaling Events Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram

Diseases associated with BCA-1 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>152 publications with BCA-1 and Inflammation
Necrosis Antibodies	>58 publications with BCA-1 and Necrosis
Disease Models, Animal Antibodies	>47 publications with BCA-1 and Disease Models, Animal
Carcinoma Antibodies	>30 publications with BCA-1 and Carcinoma
Lung Diseases Antibodies	>29 publications with BCA-1 and Lung Diseases
Hyperplasia Antibodies	>19 publications with BCA-1 and Hyperplasia
Neoplasms, Experimental Antibodies	>18 publications with BCA-1 and Neoplasms, Experimental
Liver Diseases Antibodies	>13 publications with BCA-1 and Liver Diseases
Adenocarcinoma Antibodies	>12 publications with BCA-1 and Adenocarcinoma
Skin Neoplasms Antibodies	>10 publications with BCA-1 and Skin Neoplasms

Organs/Tissues associated with BCA-1 active protein

Organ/Tissue Name	Pubmed Publications
Lymph Node Antibodies	>178 publications with BCA-1 and Lymph Node
Spleen Antibodies	>78 publications with BCA-1 and Spleen
Bone Antibodies	>67 publications with BCA-1 and Bone
Vascular Antibodies	>66 publications with BCA-1 and Vascular
Lung Antibodies	>43 publications with BCA-1 and Lung
Kidney Antibodies	>23 publications with BCA-1 and Kidney
Intestine Antibodies	>20 publications with BCA-1 and Intestine
Pharynx Antibodies	>20 publications with BCA-1 and Pharynx
Muscle Antibodies	>19 publications with BCA-1 and Muscle
Prostate Antibodies	>18 publications with BCA-1 and Prostate