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IL-33 Mouse Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695934

IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. It binds and signals through the IL-1RL1/ST2 receptor activating NF-kappaB and MAP kinases. IL-33 induces production of TH2 cell related… More details

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Product Overview

Product Name
IL-33, Active Protein
Full Product Name
Murine IL-33
Product Gene Name
IL-33 active protein
Product Synonym Names
Recombinant Murine IL-33
Sequence
SIQGTSLLT QSPASLSTY NDQSVSFVL ENGCYVINV DDSGKDQEQ DQVLLRYYE SPCPASQSG DGVDGKKLM VNMSPIKDT DIWLHANDK DYSVELQRG DVSPPEQAF FVLHKKSSD FVSFECKNL PGTYIGVKD NQLALVEEK DESCNNIMF KLSKI
Host
E Coli
Species Reactivity
Species Reactivity: Mouse
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Preparation and Storage
At -20 degree C
Molecular Weight
29,991 Da
3D Structure
ModBase 3D Structure for Q8BVZ5
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine D10S cells is <= 0.5 ng/ml, corresponding to a specific activity of >= 2 x 106units/mg.

Product Categories/Family for IL-33 active protein

Immunology; Inflammation

Other Notes

Small volumes of IL-33 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-33 purchase

MBS695934 is an active protein targeting IL-33. Also known as Murine IL-33. Reactive in Species Reactivity: Mouse. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-33. It may not necessarily be applicable to this product.

NCBI GI #
68565902
NCBI GeneID
77125
NCBI Accession #
Q8BVZ5.1
UniProt Primary Accession #
Q8BVZ5
UniProt Secondary Accession #
Q2YEJ4; Q3TQN0; Q99L46
UniProt Related Accession #
Q8BVZ5
NCBI Official Full Name
Interleukin-33
NCBI Official Synonym Full Names
interleukin 33
NCBI Official Symbol
Il33
NCBI Official Synonym Symbols
Il-33; Il1f11; NF-HEV; 9230117N10Rik
UniProt Protein Name
Interleukin-33
UniProt Gene Name
Il33
UniProt Synonym Gene Names
IL-33
UniProt Entry Name
IL33_MOUSE
NCBI Protein Information
interleukin-33; nuclear factor from high endothelial venules

UniProt Comments for IL-33

IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Cellular Component: extracellular space; extracellular region; chromosome; cytoplasmic vesicle; nucleus

Molecular Function: cytokine activity

Biological Process: negative regulation of T-helper 1 type immune response; positive regulation of T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of interleukin-6 production; positive regulation of immunoglobulin secretion; negative regulation of leukocyte migration; positive regulation of interleukin-4 production; negative regulation of immunoglobulin secretion; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-13 production; defense response to virus; positive regulation of interleukin-5 production; positive regulation of macrophage activation; positive regulation of inflammatory response
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Research Articles on IL-33

1. mouse bone marrow-derived mast cells are capable of producing and serving as endogenous sources of IL-33, and IL-33 plays an important role in regulating mast cell functions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IL-33 active protein

 Products by Pathway  Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram

Diseases associated with IL-33 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >174 publications with IL-33 and Inflammation
 Asthma Antibodies  >83 publications with IL-33 and Asthma
 Hypersensitivity, Immediate Antibodies  >80 publications with IL-33 and Hypersensitivity, Immediate
 Lung Diseases Antibodies  >77 publications with IL-33 and Lung Diseases
 Necrosis Antibodies  >53 publications with IL-33 and Necrosis
 Heart Diseases Antibodies  >27 publications with IL-33 and Heart Diseases
 Dermatitis, Atopic Antibodies  >18 publications with IL-33 and Dermatitis, Atopic
 Disease Models, Animal Antibodies  >17 publications with IL-33 and Disease Models, Animal
 Nervous System Diseases Antibodies  >12 publications with IL-33 and Nervous System Diseases
 Liver Diseases Antibodies  >11 publications with IL-33 and Liver Diseases

Organs/Tissues associated with IL-33 active protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >51 publications with IL-33 and Lung
 Skin Antibodies  >41 publications with IL-33 and Skin
 Muscle Antibodies  >19 publications with IL-33 and Muscle
 Bone Antibodies  >19 publications with IL-33 and Bone
 Brain Antibodies  >11 publications with IL-33 and Brain
 Lymph Node Antibodies  >10 publications with IL-33 and Lymph Node
 Eye Antibodies  >9 publications with IL-33 and Eye
 Spleen Antibodies  >6 publications with IL-33 and Spleen
 Connective Tissue Antibodies  >6 publications with IL-33 and Connective Tissue
 Stomach Antibodies  >5 publications with IL-33 and Stomach
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