Human BMP-5 Active Protein – Cat# MBS695966

BMP-5 Human Active Protein

Name: BMP-5 Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS695966
Price: 180 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695966

TGF-beta family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

BMP-5, Active Protein

Full Product Name

Human BMP-5

Product Gene Name

BMP-5 active protein

Product Synonym Names

Recombinant Human BMP-5

Sequence

AANKRKNQN RNKSSSHQD SSRMSSVGD YNTSEQKQA CKKHELYVS FRDLGWQDW IIAPEGYAA FYCDGECSF PLNAHMNAT NHAIVQTLV HLMFPDHVP KPCCAPTKL NAISVLYFD DSSNVILKK YRNMVVRSC GCH

Host

CHO cells

Species Reactivity

Species Reactivity: Human

Purity/Purification

Above 95% as determined by SDS-PAGE Analysis.

Preparation and Storage

At -20 degree C

Molecular Weight

47,670 Da

OMIM

112265

3D Structure

ModBase 3D Structure for P22003

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.0 mug/ml.

Product Categories/Family for BMP-5 active protein

Apoptosis; Neurosciences; Bone Biology; Proliferation and Cell Cycle

Other Notes

Small volumes of BMP-5 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BMP-5 purchase

MBS695966 is an active protein targeting BMP-5. Also known as Human BMP-5. Reactive in Species Reactivity: Human. Host: CHO cells.

Additional Details

NCBI/Uniprot data below describe general gene information for BMP-5. It may not necessarily be applicable to this product.

NCBI GI #

115075

NCBI GeneID

653

NCBI Accession #

P22003.1

UniProt Primary Accession #

P22003

UniProt Secondary Accession #

Q9H547; Q9NTM5; B4E0Y4

UniProt Related Accession #

P22003

NCBI Official Full Name

Bone morphogenetic protein 5

NCBI Official Synonym Full Names

bone morphogenetic protein 5

NCBI Official Symbol

BMP5

UniProt Protein Name

Bone morphogenetic protein 5

Protein Family

Bone morphogenetic protein

UniProt Gene Name

BMP5

UniProt Synonym Gene Names

BMP-5

UniProt Entry Name

BMP5_HUMAN

NCBI Protein Information

bone morphogenetic protein 5; BMP-5; bone morphogenenic protein-5

NCBI Summary for BMP-5

This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors. [provided by RefSeq, Jul 2008]

UniProt Comments for BMP-5

BMP5: Induces cartilage and bone formation. Belongs to the TGF-beta family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p12.1

Cellular Component: extracellular space

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: ossification; negative regulation of insulin-like growth factor receptor signaling pathway; pattern specification process; BMP signaling pathway; regulation of apoptosis; negative regulation of cell proliferation; cartilage development; regulation of MAPKKK cascade; negative regulation of aldosterone biosynthetic process; male genitalia development; positive regulation of transcription from RNA polymerase II promoter; skeletal development; positive regulation of epithelial cell proliferation; growth

Research Articles on BMP-5

1. BMP5, is elevated in the stenotic colon segment of Hirschsprung disease patients, and BMP5 signaling may play a pivotal role in disease development.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BMP-5 active protein

Reference Product	PubMed Publications
BMPR1A active protein	>4 publications with BMP-5 and BMPR1A
BMPR2 active protein	>3 publications with BMP-5 and BMPR2
FST active protein	>2 publications with BMP-5 and FST
AMHR2 active protein	>1 publications with BMP-5 and AMHR2
SOST active protein	>1 publications with BMP-5 and SOST

Pathways associated with BMP-5 active protein

Products by Pathway	Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram
Hippo Signaling Pathway antibodies	Hippo Signaling Pathway Diagram
TGF-beta Signaling Pathway antibodies	TGF-beta Signaling Pathway Diagram
TGF-beta Signaling Pathway antibodies	TGF-beta Signaling Pathway Diagram

Diseases associated with BMP-5 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>6 publications with BMP-5 and Inflammation
Carcinoma Antibodies	>4 publications with BMP-5 and Carcinoma
Nervous System Diseases Antibodies	>4 publications with BMP-5 and Nervous System Diseases
Necrosis Antibodies	>3 publications with BMP-5 and Necrosis
Cell Transformation, Neoplastic Antibodies	>2 publications with BMP-5 and Cell Transformation, Neoplastic
Hypertrophy Antibodies	>2 publications with BMP-5 and Hypertrophy
Breast Neoplasms Antibodies	>2 publications with BMP-5 and Breast Neoplasms
Hyperplasia Antibodies	>2 publications with BMP-5 and Hyperplasia
Neoplasm Metastasis Antibodies	>1 publications with BMP-5 and Neoplasm Metastasis
Anemia Antibodies	>1 publications with BMP-5 and Anemia

Organs/Tissues associated with BMP-5 active protein

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>22 publications with BMP-5 and Embryonic Tissue
Connective Tissue Antibodies	>16 publications with BMP-5 and Connective Tissue
Muscle Antibodies	>12 publications with BMP-5 and Muscle
Brain Antibodies	>9 publications with BMP-5 and Brain
Heart Antibodies	>8 publications with BMP-5 and Heart
Prostate Antibodies	>5 publications with BMP-5 and Prostate
Lung Antibodies	>4 publications with BMP-5 and Lung
Eye Antibodies	>4 publications with BMP-5 and Eye
Liver Antibodies	>4 publications with BMP-5 and Liver
Pancreas Antibodies	>3 publications with BMP-5 and Pancreas