Human VEGF-B Active Protein – Cat# MBS696001

VEGF-B Human Active Protein

Name: VEGF-B Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS696001
Price: 180 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS696001

VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, helps regulate angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

VEGF-B, Active Protein

Full Product Name

Human VEGF-B

Product Gene Name

VEGF-B active protein

Product Synonym Names

Recombinant Human VEGF-B

Sequence

PVSQPDAPG HQRKVVSWI DVYTRATCQ PREVVVPLT VELMGTVAK QLVPSCVTV QRCGGCCPD DGLECVPTG QHQVRMQIL MIRYPSSQL GEMSLEEHS QCECRPKKK DSAVKPDSP RPLCPRCTQ HHQRPDPRT CRCRCRRRS FLRCQGRGL ELNPDTCRC RKLRR

Host

E Coli

Species Reactivity

Species Reactivity: Human

Purity/Purification

Above 98% as determined by SDS-PAGE Analysis.

Preparation and Storage

At -20 degree C

Molecular Weight

21,261 Da

OMIM

601398

3D Structure

ModBase 3D Structure for P49765

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) in the presence of human VEGF165. The expected ED50 for this effect is 1.0-2.0 mug/ml.

Cell Type

Endothelial Cells, Neurons

Product Categories/Family for VEGF-B active protein

Cancer; Angiogenesis; Inflammation; Proliferation and Cell Cycle

Other Notes

Small volumes of VEGF-B active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VEGF-B purchase

MBS696001 is an active protein targeting VEGF-B. Also known as Human VEGF-B. Reactive in Species Reactivity: Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for VEGF-B. It may not necessarily be applicable to this product.

UniProt Primary Accession #

P49765

UniProt Secondary Accession #

Q16528

UniProt Protein Name

Vascular endothelial growth factor B

UniProt Synonym Protein Names

VEGF-related factor; VRF

Protein Family

Vascular endothelial growth factor

UniProt Gene Name

VEGFB

UniProt Synonym Gene Names

VRF; VEGF-B; VRF

UniProt Entry Name

VEGFB_HUMAN

UniProt Comments for VEGF-B

VEGFB: Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. Homodimer; disulfide-linked. Can also form heterodimer with VEGF. Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Cell cycle regulation; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: extracellular space; membrane; extracellular region

Molecular Function: heparin binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; vascular endothelial growth factor receptor 1 binding; chemoattractant activity

Biological Process: response to drug; protein amino acid O-linked glycosylation; platelet activation; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of vascular permeability; induction of positive chemotaxis; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; platelet degranulation; positive chemotaxis; positive regulation of cell division; positive regulation of endothelial cell proliferation; negative regulation of neuron apoptosis; angiogenesis; blood coagulation; vascular endothelial growth factor receptor signaling pathway; negative regulation of apoptosis; cardiac muscle contraction

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with VEGF-B active protein

Reference Product	PubMed Publications
FLT1 active protein	>10 publications with VEGF-B and FLT1
KDR active protein	>6 publications with VEGF-B and KDR
NRP1 active protein	>4 publications with VEGF-B and NRP1
FLT4 active protein	>3 publications with VEGF-B and FLT4
ERBB2 active protein	>1 publications with VEGF-B and ERBB2
EGFR active protein	>1 publications with VEGF-B and EGFR

Diseases associated with VEGF-B active protein

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>11 publications with VEGF-B and Heart Diseases
Nervous System Diseases Antibodies	>8 publications with VEGF-B and Nervous System Diseases
Neoplasm Invasiveness Antibodies	>7 publications with VEGF-B and Neoplasm Invasiveness
Hypertrophy Antibodies	>7 publications with VEGF-B and Hypertrophy
Edema Antibodies	>7 publications with VEGF-B and Edema
Inflammation Antibodies	>6 publications with VEGF-B and Inflammation
Liver Diseases Antibodies	>5 publications with VEGF-B and Liver Diseases
Liver Neoplasms Antibodies	>5 publications with VEGF-B and Liver Neoplasms
Neoplasm Metastasis Antibodies	>5 publications with VEGF-B and Neoplasm Metastasis
Hypertension Antibodies	>5 publications with VEGF-B and Hypertension

Organs/Tissues associated with VEGF-B active protein

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>93 publications with VEGF-B and Vascular
Blood Antibodies	>38 publications with VEGF-B and Blood
Heart Antibodies	>16 publications with VEGF-B and Heart
Muscle Antibodies	>14 publications with VEGF-B and Muscle
Brain Antibodies	>10 publications with VEGF-B and Brain
Lung Antibodies	>9 publications with VEGF-B and Lung
Placenta Antibodies	>7 publications with VEGF-B and Placenta
Liver Antibodies	>7 publications with VEGF-B and Liver
Eye Antibodies	>7 publications with VEGF-B and Eye
Kidney Antibodies	>5 publications with VEGF-B and Kidney