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Betacellulin (BTC) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS696023

Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
Betacellulin (BTC), Active Protein
Full Product Name
Human Betacellulin
Product Gene Name
BTC active protein
Product Synonym Names
Recombinant Human Betacellulin
Sequence
DGNSTRSPE TNGLLCGDP EENCAATTT QSKRKGHFS RCPKQYKHY CIKGRCRFV VAEQTPSCV CDEGYIGAR CERVDLFY
Host
E Coli
Species Reactivity
Species Reactivity: Human
Cross Reactivity: Mouse
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Preparation and Storage
At -20 degree C
Molecular Weight
19,746 Da
OMIM
600345
3D Structure
ModBase 3D Structure for P35070
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is <= 0.05 ng/ml, 7units/mg.

Testing Data of BTC active protein

Human BTC Active Protein – Cat# MBS696023

Other Notes

Small volumes of BTC active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BTC purchase

MBS696023 is an active protein targeting BTC. Also known as Human Betacellulin. Reactive in Species Reactivity: Human
Cross Reactivity: Mouse. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BTC. It may not necessarily be applicable to this product.

NCBI GI #
461653
NCBI GeneID
685
NCBI Accession #
P35070.1
UniProt Primary Accession #
P35070
UniProt Secondary Accession #
Q96F48
UniProt Related Accession #
P35070
NCBI Official Full Name
Probetacellulin
NCBI Official Synonym Full Names
betacellulin
NCBI Official Symbol
BTC
UniProt Protein Name
Probetacellulin
Protein Family
Probetacellulin
UniProt Gene Name
BTC
UniProt Synonym Gene Names
BTC
UniProt Entry Name
BTC_HUMAN
NCBI Protein Information
probetacellulin

NCBI Summary for BTC

The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor. [provided by RefSeq, Jul 2008]

UniProt Comments for BTC

BTC: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

Protein type: Cell cycle regulation; Ligand, receptor tyrosine kinase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; extracellular region; integral to membrane; plasma membrane

Molecular Function: protein binding; growth factor activity; epidermal growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of fibroblast proliferation; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; positive regulation of mitosis; nerve growth factor receptor signaling pathway; positive regulation of cell proliferation; innate immune response; positive regulation of cell differentiation; negative regulation of apoptosis
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Research Articles on BTC

1. CXCL8 production from lung cancer cells could be initiated by an autocrine mechanism or external sources of BTC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BTC active protein

 Reference Product  PubMed Publications
 EGFR active protein  >67 publications with BTC and EGFR
 ERBB2 active protein  >35 publications with BTC and ERBB2
 ERBB4 active protein  >22 publications with BTC and ERBB4
 EREG active protein  >18 publications with BTC and EREG
 INS active protein  >6 publications with BTC and INS
 NRG1 active protein  >6 publications with BTC and NRG1
 HBEGF active protein  >4 publications with BTC and HBEGF
 NRG2 active protein  >3 publications with BTC and NRG2
 NRG4 active protein  >2 publications with BTC and NRG4

Pathways associated with BTC active protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 ErbB Receptor Signaling Network Pathway antibodies  ErbB Receptor Signaling Network Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram

Diseases associated with BTC active protein

 Disease Name  Pubmed Publications
 Liver Neoplasms Antibodies  >29 publications with BTC and Liver Neoplasms
 Disease Models, Animal Antibodies  >28 publications with BTC and Disease Models, Animal
 Liver Diseases Antibodies  >25 publications with BTC and Liver Diseases
 Anemia Antibodies  >16 publications with BTC and Anemia
 Necrosis Antibodies  >15 publications with BTC and Necrosis
 Carcinoma, Hepatocellular Antibodies  >13 publications with BTC and Carcinoma, Hepatocellular
 Inflammation Antibodies  >12 publications with BTC and Inflammation
 Neoplasm Metastasis Antibodies  >10 publications with BTC and Neoplasm Metastasis
 Brain Diseases Antibodies  >7 publications with BTC and Brain Diseases
 Urinary Bladder Neoplasms Antibodies  >6 publications with BTC and Urinary Bladder Neoplasms

Organs/Tissues associated with BTC active protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >66 publications with BTC and Liver
 Ovary Antibodies  >27 publications with BTC and Ovary
 Brain Antibodies  >18 publications with BTC and Brain
 Kidney Antibodies  >12 publications with BTC and Kidney
 Prostate Antibodies  >9 publications with BTC and Prostate
 Connective Tissue Antibodies  >6 publications with BTC and Connective Tissue
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