Human MIP-1beta Active Protein – Cat# MBS696045

MIP-1beta Human Active Protein

Name: MIP-1beta Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS696045
Price: 180 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS696045

Both MIP-1 alpha and MIP-1beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

MIP-1beta, Active Protein

Full Product Name

Human MIP-1beta (CCL4)

Product Gene Name

MIP-1beta active protein

Product Synonym Gene Name

CCL4

Product Synonym Names

Recombinant Human MIP-1beta (CCL4)

Sequence

APMGSDPPT ACCFSYTAR KLPHNFVVD YYETSSLCS QPAVVFQTK RGKQVCADP SESWVQEYV YDLELN

Host

E Coli

Species Reactivity

Species Reactivity: Human
Cross Reactivity: Hamster, Monkey, Mouse, Rat

Purity/Purification

Above 98% as determined by SDS-PAGE Analysis.

Preparation and Storage

At -20 degree C

Molecular Weight

11,008 Da

OMIM

gene 610757

3D Structure

ModBase 3D Structure for Q8NHW4

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/ml.

Cell Type

Monocytes and Macrophages, NK and NKT Cells

Product Categories/Family for MIP-1beta active protein

Immunology; Neurosciences; Inflammation; Chemotaxis

Other Notes

Small volumes of MIP-1beta active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MIP-1beta purchase

MBS696045 is an active protein targeting MIP-1beta. Also known as Human MIP-1beta (CCL4). Reactive in Species Reactivity: Human
Cross Reactivity: Hamster, Monkey, Mouse, Rat. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for MIP-1beta. It may not necessarily be applicable to this product.

NCBI GI #

74727347

NCBI GeneID

388372

NCBI Accession #

Q8NHW4.1

UniProt Primary Accession #

Q8NHW4

UniProt Secondary Accession #

Q50EM1; Q50EM2; Q50EM3; Q50EM4; Q50EM5; Q50EM6; Q50EM7; Q50EM8; Q569J2; B2RUZ3; B7ZMA8

NCBI Official Full Name

C-C motif chemokine 4-like

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 4-like 1

NCBI Official Symbol

CCL4L1

NCBI Official Synonym Symbols

LAG1; CCL4L; LAG-1; SCYA4L; AT744.2; SCYA4L1

UniProt Protein Name

C-C motif chemokine 4-like

UniProt Synonym Protein Names

Lymphocyte activation gene 1 protein; LAG-1; Macrophage inflammatory protein 1-beta; MIP-1-beta; Monocyte adherence-induced protein 5-alpha; Small-inducible cytokine A4-like

UniProt Gene Name

CCL4L1

UniProt Synonym Gene Names

CCL4L; LAG1; SCYA4L1; LAG-1; MIP-1-beta

UniProt Entry Name

CC4L_HUMAN

NCBI Protein Information

C-C motif chemokine 4-like; CC chemokine ligand 4L1; lymphocyte activation gene 1; small inducible cytokine A4-like; macrophage inflammatory protein-1b2; chemokine (C-C motif) ligand 4-like 1, telomeric

NCBI Summary for MIP-1beta

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

UniProt Comments for MIP-1beta

CCL4L1: Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5. Belongs to the intercrine beta (chemokine CC) family. 10 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Chemokine; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q12

Research Articles on MIP-1beta

1. CCL4L1 allele frequency is higher in severe psoriasis, whereas CCL4L2 is more frequent in patients with a milder disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with MIP-1beta active protein

Products by Pathway	Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
IL12-mediated Signaling Events Pathway antibodies	IL12-mediated Signaling Events Pathway Diagram
NF-kappa B Signaling Pathway antibodies	NF-kappa B Signaling Pathway Diagram
Salmonella Infection Pathway antibodies	Salmonella Infection Pathway Diagram
Salmonella Infection Pathway antibodies	Salmonella Infection Pathway Diagram

Diseases associated with MIP-1beta active protein

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>4 publications with MIP-1beta and Immune System Diseases
Disease Susceptibility Antibodies	>3 publications with MIP-1beta and Disease Susceptibility
Diabetes Mellitus Antibodies	>1 publications with MIP-1beta and Diabetes Mellitus

Organs/Tissues associated with MIP-1beta active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>5 publications with MIP-1beta and Blood
Kidney Antibodies	>2 publications with MIP-1beta and Kidney
Liver Antibodies	>1 publications with MIP-1beta and Liver
Lung Antibodies	>1 publications with MIP-1beta and Lung