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CDNF Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS696046

CDNF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. CDNF and its structural homolog MANF, each contain an… More details

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Product Overview

Product Name
CDNF, Active Protein
Full Product Name
Human CDNF
Product Gene Name
Product Synonym Names
Recombinant Human CDNF
Sequence
MQEAGGRPG ADCEVCKEF LNRFYKSLI DRGVNFSLD TIEKELISF CLDTKGKEN RLCYYLGAT KDAATKILS EVTRPMSVH MPAMKICEK LKKLDSQIC ELKYEKTLD LASVDLRKM RVAELKQIL HSWGEECRA CAEKTDYVN LIQELAPKY AATHPKTEL
Host
E Coli
Species Reactivity
Species Reactivity: Human
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Preparation and Storage
At -20 degree C
Molecular Weight
9,806 Da
OMIM
611233
3D Structure
ModBase 3D Structure for Q49AH0
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 mug/ml.
Cell Type
Neurons

Product Categories/Family for CDNF active protein

Other Notes

Small volumes of CDNF active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDNF purchase

MBS696046 is an active protein targeting CDNF. Also known as Human CDNF. Reactive in Species Reactivity: Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for CDNF. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Cerebral dopamine neurotrophic factor
NCBI Official Synonym Full Names
cerebral dopamine neurotrophic factor
NCBI Official Symbol
CDNF
NCBI Official Synonym Symbols
ARMETL1
UniProt Protein Name
Cerebral dopamine neurotrophic factor
UniProt Synonym Protein Names
ARMET-like protein 1; Conserved dopamine neurotrophic factor
UniProt Gene Name
CDNF
UniProt Synonym Gene Names
ARMETL1
UniProt Entry Name
CDNF_HUMAN
NCBI Protein Information
cerebral dopamine neurotrophic factor; ARMET-like protein 1; conserved dopamine neurotrophic factor; arginine-rich, mutated in early stage tumors-like 1

UniProt Comments for CDNF

ARMETL1: Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra. Belongs to the ARMET family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: extracellular region

Molecular Function: growth factor activity
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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