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Betacellulin (BTC) Mouse Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS696083

Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment… More details

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Product Overview

Product Name
Betacellulin (Btc), Active Protein
Full Product Name
Murine Betacellulin
Product Gene Name
Product Synonym Names
Recombinant Murine Betacellulin
Sequence
DGNTTRTPE TNGSLCGAP GENCTGTTP RQKVKTHFS RCPKQYKHY CIHGRCRFV VDEQTPSCI CEKGYFGAR CERVDLFY
Host
E Coli
Species Reactivity
Species Reactivity: Mouse
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Preparation and Storage
At -20 degree C
Molecular Weight
19,664 Da
3D Structure
ModBase 3D Structure for Q05928
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Determined by its ability to stimulate the proliferation of mouse Balb/3T3 cells. The expected ED50 is <= 0.01 ng/ml, corresponding to a specific activity of >= 1 x 108 units/mg.

Other Notes

Small volumes of Btc active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Btc purchase

MBS696083 is an active protein targeting Btc. Also known as Murine Betacellulin. Reactive in Species Reactivity: Mouse. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Btc. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
Probetacellulin
NCBI Official Synonym Full Names
betacellulin, epidermal growth factor family member
NCBI Official Symbol
Btc
NCBI Official Synonym Symbols
Bcn
UniProt Protein Name
Probetacellulin
Protein Family
UniProt Gene Name
Btc
UniProt Synonym Gene Names
Bcn; BTC
UniProt Entry Name
BTC_MOUSE
NCBI Protein Information
betacellulin; probetacellulin

NCBI Summary for Btc

This gene encodes a member of the epidermal growth factor (EGF) family. These growth factors are ligands for the EGFR/ErbB receptor tyrosine kinases, and play roles in cell growth and differentiation. The encoded protein is synthesized as a transmembrane precursor that is proteolytically cleaved to generate a mature peptide, and plays a role in the differentiation of pancreatic beta cells. This gene may also play a protective role in acute pancreatitis, whereas increased expression of this gene may contribute to diabetic macular edema. Gene therapy using combinations of this gene and other pancreas-specific transcription factors may induce islet neogenesis and remediate hyperglycemia in type 1 diabetes. [provided by RefSeq, Apr 2011]
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UniProt Comments for Btc

BTC: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

Protein type: Ligand, receptor tyrosine kinase; Cell cycle regulation; Membrane protein, integral

Cellular Component: extracellular space; membrane; integral to membrane; plasma membrane; extracellular region

Molecular Function: growth factor activity; epidermal growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of fibroblast proliferation; positive regulation of mitosis; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of cell differentiation; negative regulation of apoptosis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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