Human IGF-BP4 Active Protein – Cat# MBS696094

IGF-BP4 Human Active Protein

Name: IGF-BP4 Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS696094
Price: 180 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS696094

IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP4 is the major IGF-BP produced by osteoblasts, and is also found in the epidermis, ovarian follicles, and other tissues. IGF-BP4 inhibits the… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IGF-BP4, Active Protein

Full Product Name

Human IGF-BP4

Product Gene Name

IGF-BP4 active protein

Product Synonym Names

Recombinant Human IGF-BP4

Sequence

DEAIHCPPC SEEKLARCR PPVGCEELV REPGCGCCA TCALGLGMP CGVYTPRCG SGLRCYPPR GVEKPLHTL MHGQGVCME LAEIEAIQE SLQPSDKDE GDHPNNSFS PCSAHDRRC LQKHFAKIR DRSTSGGKM KVNGAPRED ARPVPQGSC QSELHRALE RLAASQSRT HEDLYIIPI PNCDRNGNF HPKQCHPAL DGQRGKCWC VDRKTGVKL PGGLEPKGE LDCHQLADS FRE

Host

(BTI-Tn-5B1-4) Hi-5 Insect cells*

Species Reactivity

Species Reactivity: Human
Cross Reactivity: Mouse

Purity/Purification

Above 95% as determined by SDS-PAGE Analysis.

Preparation and Storage

At -20 degree C

Molecular Weight

17,635 Da

OMIM

146733

3D Structure

ModBase 3D Structure for P22692

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.

Product Categories/Family for IGF-BP4 active protein

Apoptosis; Cancer; Proliferation and Cell Cycle

Other Notes

Small volumes of IGF-BP4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IGF-BP4 purchase

MBS696094 is an active protein targeting IGF-BP4. Also known as Human IGF-BP4. Reactive in Species Reactivity: Human
Cross Reactivity: Mouse. Host: (BTI-Tn-5B1-4) Hi-5 Insect cells*.

Additional Details

NCBI/Uniprot data below describe general gene information for IGF-BP4. It may not necessarily be applicable to this product.

NCBI GI #

124065

NCBI GeneID

3487

NCBI Accession #

P22692.2

UniProt Primary Accession #

P22692

UniProt Secondary Accession #

Q5U012; Q9UCL6; A0N9W2; B4E351

UniProt Related Accession #

P22692

NCBI Official Full Name

Insulin-like growth factor-binding protein 4

NCBI Official Synonym Full Names

insulin-like growth factor binding protein 4

NCBI Official Symbol

IGFBP4

NCBI Official Synonym Symbols

BP-4; IBP4; IGFBP-4; HT29-IGFBP

UniProt Protein Name

Insulin-like growth factor-binding protein 4

UniProt Gene Name

IGFBP4

UniProt Synonym Gene Names

IBP4; IBP-4; IGF-binding protein 4; IGFBP-4

UniProt Entry Name

IBP4_HUMAN

NCBI Protein Information

insulin-like growth factor-binding protein 4; IBP-4; IGF-binding protein 4

NCBI Summary for IGF-BP4

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]

UniProt Comments for IGF-BP4

IGFBP4: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: extracellular space; extracellular region

Molecular Function: insulin-like growth factor I binding; insulin-like growth factor II binding

Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; cell proliferation; regulation of insulin-like growth factor receptor signaling pathway; cellular protein metabolic process; positive regulation of MAPKKK cascade; regulation of cell growth; inflammatory response; signal transduction; skeletal development; DNA metabolic process

Research Articles on IGF-BP4

1. IGF-1/IGFbp4 signaling regulated the post-developmental adipose tissue expansion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IGF-BP4 active protein

Reference Product	PubMed Publications
IGFBP1 active protein	>146 publications with IGF-BP4 and IGFBP1
IGF1 active protein	>23 publications with IGF-BP4 and IGF1
PTH active protein	>18 publications with IGF-BP4 and PTH
IGF2 active protein	>17 publications with IGF-BP4 and IGF2
PAPPA active protein	>8 publications with IGF-BP4 and PAPPA
TGFB1 active protein	>3 publications with IGF-BP4 and TGFB1
WNT3A active protein	>2 publications with IGF-BP4 and WNT3A
LRP6 active protein	>1 publications with IGF-BP4 and LRP6

Pathways associated with IGF-BP4 active protein

Products by Pathway	Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Myometrial Relaxation And Contraction Pathways antibodies	Myometrial Relaxation And Contraction Pathways Diagram
Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies	Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram
Wnt Signaling Network Pathway antibodies	Wnt Signaling Network Pathway Diagram

Diseases associated with IGF-BP4 active protein

Disease Name	Pubmed Publications
Carcinoma Antibodies	>48 publications with IGF-BP4 and Carcinoma
Cardiovascular Diseases Antibodies	>29 publications with IGF-BP4 and Cardiovascular Diseases
Breast Neoplasms Antibodies	>28 publications with IGF-BP4 and Breast Neoplasms
Hypertrophy Antibodies	>25 publications with IGF-BP4 and Hypertrophy
Adenocarcinoma Antibodies	>21 publications with IGF-BP4 and Adenocarcinoma
Nervous System Diseases Antibodies	>20 publications with IGF-BP4 and Nervous System Diseases
Necrosis Antibodies	>20 publications with IGF-BP4 and Necrosis
Kidney Diseases Antibodies	>19 publications with IGF-BP4 and Kidney Diseases
Inflammation Antibodies	>19 publications with IGF-BP4 and Inflammation
Weight Loss Antibodies	>15 publications with IGF-BP4 and Weight Loss

Organs/Tissues associated with IGF-BP4 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>196 publications with IGF-BP4 and Blood
Bone Antibodies	>109 publications with IGF-BP4 and Bone
Muscle Antibodies	>105 publications with IGF-BP4 and Muscle
Ovary Antibodies	>103 publications with IGF-BP4 and Ovary
Liver Antibodies	>73 publications with IGF-BP4 and Liver
Vascular Antibodies	>65 publications with IGF-BP4 and Vascular
Connective Tissue Antibodies	>54 publications with IGF-BP4 and Connective Tissue
Kidney Antibodies	>53 publications with IGF-BP4 and Kidney
Brain Antibodies	>40 publications with IGF-BP4 and Brain
Embryonic Tissue Antibodies	>33 publications with IGF-BP4 and Embryonic Tissue