Mouse LIX Active Protein – Cat# MBS696098

LIX / CXCL6 (LIX) Mouse Active Protein

Name: LIX Active Protein; LIX / CXCL6; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS696098
Price: 180 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS696098

LIX is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. LIX is a chemoattractant for neutrophils. The two naturally occurring variants of LIX; LIX 1-78 (GCP-2) and LIX 9-78… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

LIX / CXCL6, Active Protein

Full Product Name

Murine LIX / CXCL6 (70 a.a.)

Product Gene Name

LIX active protein

Product Synonym Gene Name

CXCL6

Product Synonym Names

Recombinant Murine LIX (CXCL6) [70a.a.]

Sequence

TELRCVCLT VTPKINPKL IANLEVIPA GPQCPTVEV IAKLKNQKE VCLDPEAPV IKKIIQKIL GSDKKKA

Host

E Coli

Species Reactivity

Species Reactivity: Mouse
Cross Reactivity: Human

Purity/Purification

Above 98% as determined by SDS-PAGE Analysis.

Preparation and Storage

At -20 degree C

Molecular Weight

14,235 Da

3D Structure

ModBase 3D Structure for P50228

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Determined by its ability to chemoattract human neutrophils using a concentration range of 10.0-100.0 ng/ml.

Cell Type

Monocytes and Macrophages, Endothelial Cells

Product Categories/Family for LIX active protein

Angiogenesis; Inflammation; Chemotaxis

Other Notes

Small volumes of LIX active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LIX purchase

MBS696098 is an active protein targeting LIX. Also known as Murine LIX / CXCL6 (70 a.a.). Reactive in Species Reactivity: Mouse
Cross Reactivity: Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for LIX. It may not necessarily be applicable to this product.

NCBI GI #

408360041

NCBI GeneID

20311

NCBI Accession #

P50228.2

UniProt Primary Accession #

P50228

UniProt Secondary Accession #

Q8K3I3

UniProt Related Accession #

P50228

NCBI Official Full Name

C-X-C motif chemokine 5

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 5

NCBI Official Symbol

Cxcl5

NCBI Official Synonym Symbols

LIX; GCP-2; Scyb5; Scyb6; ENA-78; AMCF-II

UniProt Protein Name

C-X-C motif chemokine 5

UniProt Synonym Protein Names

Cytokine LIX; Small-inducible cytokine B5Cleaved into the following 2 chains:GCP-2(1-78); GCP-2(9-78)

UniProt Gene Name

Cxcl5

UniProt Synonym Gene Names

Scyb5

UniProt Entry Name

CXCL5_MOUSE

NCBI Protein Information

C-X-C motif chemokine 5; cytokine LIX; small-inducible cytokine B5; granulocyte chemotactic protein-2; small inducible cytokine B subfamily, member 5; small inducible cytokine subfamily B, member 15

NCBI Summary for LIX

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils and to have homeostatic and inflammatory functions. In mouse, deficiency of this gene is associated with increased lung inflammation that is neutrophil-dependent. [provided by RefSeq, May 2013]

UniProt Comments for LIX

CXCL6: Chemotactic for neutrophil granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity; CXCR chemokine receptor binding; cytokine activity

Biological Process: G-protein coupled receptor protein signaling pathway; organ regeneration; cytokine production; positive regulation of JAK-STAT cascade; immune response; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; inflammatory response; chemotaxis; regulation of chemokine production; regulation of cell proliferation; leukocyte homeostasis

Research Articles on LIX

1. CXCL5 regulates pulmonary responses to infection and plays a central role in conferring clock control of inflammation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LIX active protein

Reference Product	PubMed Publications
Cxcl1 active protein	>224 publications with LIX and Cxcl1
Cxcr2 active protein	>85 publications with LIX and Cxcr2
Ccl5 active protein	>73 publications with LIX and Ccl5
Ccl20 active protein	>39 publications with LIX and Ccl20
Cxcl12 active protein	>31 publications with LIX and Cxcl12
Cxcr1 active protein	>26 publications with LIX and Cxcr1
Cxcr3 active protein	>15 publications with LIX and Cxcr3
Cxcl16 active protein	>11 publications with LIX and Cxcl16
Ccr1 active protein	>8 publications with LIX and Ccr1
Ccr2 active protein	>6 publications with LIX and Ccr2

Pathways associated with LIX active protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram

Diseases associated with LIX active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>234 publications with LIX and Inflammation
Necrosis Antibodies	>100 publications with LIX and Necrosis
Respiratory Tract Diseases Antibodies	>97 publications with LIX and Respiratory Tract Diseases
Lung Diseases Antibodies	>86 publications with LIX and Lung Diseases
Disease Models, Animal Antibodies	>63 publications with LIX and Disease Models, Animal
Carcinoma Antibodies	>60 publications with LIX and Carcinoma
Cardiovascular Diseases Antibodies	>43 publications with LIX and Cardiovascular Diseases
Fibrosis Antibodies	>28 publications with LIX and Fibrosis
Lung Neoplasms Antibodies	>27 publications with LIX and Lung Neoplasms
Pneumonia Antibodies	>24 publications with LIX and Pneumonia

Organs/Tissues associated with LIX active protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>39 publications with LIX and Liver
Intestine Antibodies	>34 publications with LIX and Intestine
Eye Antibodies	>17 publications with LIX and Eye
Connective Tissue Antibodies	>16 publications with LIX and Connective Tissue
Embryonic Tissue Antibodies	>14 publications with LIX and Embryonic Tissue
Spleen Antibodies	>9 publications with LIX and Spleen
Adipose Tissue Antibodies	>8 publications with LIX and Adipose Tissue
Pancreas Antibodies	>6 publications with LIX and Pancreas
Mammary Gland Antibodies	>3 publications with LIX and Mammary Gland
Vagina Antibodies	>2 publications with LIX and Vagina