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IL-15 Mouse Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS696102

IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and… More details

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Protocol View PDF

Product Overview

Product Name
IL-15, Active Protein
Full Product Name
Murine IL-15
Product Gene Name
IL-15 active protein
Product Synonym Names
Recombinant Murine IL-15
Sequence
MNWIDVRYD LEKIESLIQ SIHIDTTLY TDSDFHPSC KVTAMNCFL LELQVILHE YSNMTLNET VRNVLYLAN STLSSNKNV AESGCKECE ELEEKTFTE FLQSFIRIV QMFINTS
Host
E Coli
Species Reactivity
Species Reactivity: Mouse
Cross Reactivity: Human
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Preparation and Storage
At -20 degree C
Molecular Weight
18,593 Da
3D Structure
ModBase 3D Structure for P48346
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
The ED50 was determined by the stimulation of the proliferation of murine CTLL-2 cells is < 5.0 ng/ml, corresponding to a specific activity of > 2 x 105 units/mg.
Cell Type
NK and NKT Cells, T Cells

Product Categories/Family for IL-15 active protein

Innate Immunity; Adaptive Immunity; Stem Cell Research; Apoptosis; Immunology; Cancer; Inflammation

Other Notes

Small volumes of IL-15 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-15 purchase

MBS696102 is an active protein targeting IL-15. Also known as Murine IL-15. Reactive in Species Reactivity: Mouse
Cross Reactivity: Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-15. It may not necessarily be applicable to this product.

NCBI GI #
1352449
NCBI GeneID
16168
NCBI Accession #
P48346.1
UniProt Primary Accession #
P48346
UniProt Related Accession #
P48346
NCBI Official Full Name
Interleukin-15
NCBI Official Synonym Full Names
interleukin 15
NCBI Official Symbol
Il15
NCBI Official Synonym Symbols
IL-15; AI503618
UniProt Protein Name
Interleukin-15
UniProt Gene Name
Il15
UniProt Synonym Gene Names
IL-15
UniProt Entry Name
IL15_MOUSE
NCBI Protein Information
interleukin-15

UniProt Comments for IL-15

IL15: Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Cell cycle regulation; Cytokine; Secreted, signal peptide

Cellular Component: nucleoplasm; extracellular space; cell surface; cytoplasm; extracellular region

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine activity

Biological Process: positive regulation of interleukin-17 production; NK T cell proliferation; positive regulation of natural killer cell proliferation; positive regulation of immune response; negative regulation of smooth muscle cell proliferation; cell maturation; signal transduction; lymph node development; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of natural killer cell differentiation; extrathymic T cell selection; natural killer cell differentiation; positive regulation of cell proliferation; immune response; regulation of T cell differentiation; positive regulation of T cell proliferation; regulation of defense response to virus by host; hyaluronan metabolic process
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Research Articles on IL-15

1. INOS expression is negatively controlled in IFN-gamma-stimulated IL-15 DCs.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with IL-15 active protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response (BioCarta) Pathway antibodies  Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with IL-15 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >347 publications with IL-15 and Inflammation
 Necrosis Antibodies  >335 publications with IL-15 and Necrosis
 Disease Models, Animal Antibodies  >170 publications with IL-15 and Disease Models, Animal
 Gastrointestinal Diseases Antibodies  >145 publications with IL-15 and Gastrointestinal Diseases
 Nervous System Diseases Antibodies  >99 publications with IL-15 and Nervous System Diseases
 Lung Diseases Antibodies  >98 publications with IL-15 and Lung Diseases
 Neoplasms, Experimental Antibodies  >94 publications with IL-15 and Neoplasms, Experimental
 Hematologic Diseases Antibodies  >88 publications with IL-15 and Hematologic Diseases
 Celiac Disease Antibodies  >70 publications with IL-15 and Celiac Disease
 Liver Diseases Antibodies  >55 publications with IL-15 and Liver Diseases

Organs/Tissues associated with IL-15 active protein

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >176 publications with IL-15 and Bone Marrow
 Spleen Antibodies  >172 publications with IL-15 and Spleen
 Intestine Antibodies  >157 publications with IL-15 and Intestine
 Liver Antibodies  >109 publications with IL-15 and Liver
 Skin Antibodies  >96 publications with IL-15 and Skin
 Joint Antibodies  >87 publications with IL-15 and Joint
 Thymus Antibodies  >73 publications with IL-15 and Thymus
 Kidney Antibodies  >69 publications with IL-15 and Kidney
 Brain Antibodies  >58 publications with IL-15 and Brain
 Heart Antibodies  >41 publications with IL-15 and Heart
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