Mouse FLT3 Active Protein – Cat# MBS696129

Flt3-Ligand (FLT3) Mouse Active Protein

Name: FLT3 Active Protein; Flt3-Ligand; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS696129
Price: 180 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS696129

Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

flt3-Ligand, Active Protein

Full Product Name

Murine flt3-Ligand

Product Gene Name

Flt3 active protein

Product Synonym Names

Recombinant Murine Flt3-Ligand

Sequence

MTPDCYFSH SPISSNFKV KFRELTDHL LKDYPVTVA VNLQDEKHC KALWSLFLA QRWIEQLKT VAGSKMQTL LEDVNTEIH FVTSCTFQP LPECLRFVQ TNISHLLKD TCTQLLALK PCIGKACQN FSRCLEVQC QPDSSTLLP PRSPIALEA TELPEPRPR Q

Host

E Coli

Species Reactivity

Species Reactivity: Mouse
Cross Reactivity: Human

Purity/Purification

Above 98% as determined by SDS-PAGE Analysis.

Preparation and Storage

At -20 degree C

Molecular Weight

28,259 Da

3D Structure

ModBase 3D Structure for P49772

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Determined by the dose-dependent stimulation of the proliferation of human AML5 cells. The expected ED50 for this effect is 5.0 - 8.0 ng/ml.

Cell Type

Stem Cells

Product Categories/Family for Flt3 active protein

Stem Cell Research; Immunology; Cancer; Proliferation and Cell Cycle

Other Notes

Small volumes of Flt3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Flt3 purchase

MBS696129 is an active protein targeting Flt3. Also known as Murine flt3-Ligand. Reactive in Species Reactivity: Mouse
Cross Reactivity: Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Flt3. It may not necessarily be applicable to this product.

NCBI GI #

1706819

NCBI GeneID

14256

NCBI Accession #

P49772.1

UniProt Primary Accession #

P49772

UniProt Secondary Accession #

Q64085

UniProt Related Accession #

P49772

NCBI Official Full Name

Fms-related tyrosine kinase 3 ligand

NCBI Official Synonym Full Names

FMS-like tyrosine kinase 3 ligand

NCBI Official Symbol

Flt3l

NCBI Official Synonym Symbols

Ly72L; Flt3lg

UniProt Protein Name

Fms-related tyrosine kinase 3 ligand

UniProt Synonym Protein Names

SL cytokine

Protein Family

Receptor-type tyrosine-protein kinase

UniProt Gene Name

Flt3lg

UniProt Synonym Gene Names

Flt3l; Flt3 ligand; Flt3L

UniProt Entry Name

FLT3L_MOUSE

NCBI Protein Information

fms-related tyrosine kinase 3 ligand; flt3 ligand

UniProt Comments for Flt3

FLT3LG: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase; Cytokine

Cellular Component: extracellular space; cell surface; membrane; plasma membrane; extracellular region; integral to membrane

Molecular Function: protein homodimerization activity; cytokine activity; receptor tyrosine kinase binding

Biological Process: positive regulation of natural killer cell differentiation; regulation of myeloid dendritic cell activation; lymphocyte differentiation; embryonic hemopoiesis; positive regulation of cell proliferation; positive regulation of protein amino acid phosphorylation; positive regulation of myoblast differentiation

Research Articles on Flt3

1. Flt3L enhances global T cell and humoral immunity as well as both the numbers and antigen capture capacity of migratory dendritic cells and classical lymphoid-resident dendritic cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Flt3 active protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Pathways In Cancer antibodies	Pathways In Cancer Diagram

Diseases associated with Flt3 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>44 publications with Flt3 and Inflammation
Disease Models, Animal Antibodies	>43 publications with Flt3 and Disease Models, Animal
Necrosis Antibodies	>32 publications with Flt3 and Necrosis
Lung Diseases Antibodies	>21 publications with Flt3 and Lung Diseases
Melanoma Antibodies	>15 publications with Flt3 and Melanoma
Liver Diseases Antibodies	>14 publications with Flt3 and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>8 publications with Flt3 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>8 publications with Flt3 and Liver Neoplasms
Anemia Antibodies	>5 publications with Flt3 and Anemia
Hepatitis Antibodies	>5 publications with Flt3 and Hepatitis

Organs/Tissues associated with Flt3 active protein

Organ/Tissue Name	Pubmed Publications
Other Antibodies	>46 publications with Flt3 and Other
Liver Antibodies	>39 publications with Flt3 and Liver
Lung Antibodies	>36 publications with Flt3 and Lung
Thymus Antibodies	>19 publications with Flt3 and Thymus
Intestine Antibodies	>9 publications with Flt3 and Intestine
Eye Antibodies	>3 publications with Flt3 and Eye
Embryonic Tissue Antibodies	>3 publications with Flt3 and Embryonic Tissue
Salivary Gland Antibodies	>2 publications with Flt3 and Salivary Gland
Spinal Cord Antibodies	>2 publications with Flt3 and Spinal Cord
Uncharacterized Tissue Antibodies	>1 publications with Flt3 and Uncharacterized Tissue