Human PLGF-1 Active Protein – Cat# MBS696135

PLGF-1 Human Active Protein

Name: PLGF-1 Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS696135
Price: 180 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS696135

PLGF-1 is an angiogenic factor that belongs to the cysteine-knot superfamily of growth factors. PLGF-1 is expressed in placental tissues, colon and mammary carcinomas. It signals through the VEGFR-1/FLT1 receptor and stimulates endothelial cell proliferation… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

PLGF-1, Active Protein

Full Product Name

Human PLGF-1

Product Gene Name

PLGF-1 active protein

Product Synonym Names

Placenta Growth Factor-1- PIGF, PGF

Sequence

MLPAVPPQQ WALSAGNGS SEVEVVPFQ EVWGRSYCR ALERLVDVV SEYPSEVEH MFSPSCVSL LRCTGCCGD ENLHCVPVE TANVTMQLL KIRSGDRPS YVELTFSQH VRCECRPLR EKMKPERCG DAVPRR

Host

E Coli

Form/Format

Sterile filtered through a 0.2 micron filter. Lyophilized from 10mM Sodium Phosphate, pH 7.5.

Purity/Purification

>=95% as determined by SDS-PAGE gel and HPLC analyses.

Preparation and Storage

At -20 degree C

OMIM

601121

3D Structure

ModBase 3D Structure for P49763

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Endotoxin

Endotoxin level is <0.1 ng/ug of protein (<1EU/ug)

Protein Content

Verified by UV Spectroscopy and/or SDS-PAGE gel.

Reconstitution

Centrifuge the vial prior to opening. Reconsitute in water to a concentreation of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Biological Activity

Determined by its ability to chemoattract human monocytes of using a concentration range of 1.0-10.0 ng/ml.

Product Categories/Family for PLGF-1 active protein

Cancer; Angiogenesis; Inflammation; Proliferation and Cell Cycle

Other Notes

Small volumes of PLGF-1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLGF-1 purchase

MBS696135 is an active protein targeting PLGF-1. Also known as Human PLGF-1. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PLGF-1. It may not necessarily be applicable to this product.

UniProt Primary Accession #

P49763

UniProt Secondary Accession #

Q07101; Q9BV78; Q9Y6S8

UniProt Protein Name

Placenta growth factor

UniProt Gene Name

PGF

UniProt Synonym Gene Names

PGFL; PLGF; PlGF

UniProt Entry Name

PLGF_HUMAN

UniProt Comments for PLGF-1

PGF: Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. Belongs to the PDGF/VEGF growth factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: extracellular space; membrane; extracellular region

Molecular Function: heparin binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity

Biological Process: response to drug; organ regeneration; female pregnancy; signal transduction; cellular response to hormone stimulus; positive regulation of angiogenesis; cell-cell signaling; ureteric bud branching; positive regulation of cell division; positive regulation of cell proliferation; response to hypoxia; positive regulation of endothelial cell proliferation; sprouting angiogenesis; cell differentiation; vascular endothelial growth factor receptor signaling pathway

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PLGF-1 active protein

Reference Product	PubMed Publications
VEGFA active protein	>24 publications with PLGF-1 and VEGFA
FLT1 active protein	>19 publications with PLGF-1 and FLT1
KDR active protein	>13 publications with PLGF-1 and KDR
EDN1 active protein	>5 publications with PLGF-1 and EDN1
NRP1 active protein	>4 publications with PLGF-1 and NRP1
FLT4 active protein	>3 publications with PLGF-1 and FLT4
AKT1 active protein	>2 publications with PLGF-1 and AKT1
PIK3CA active protein	>1 publications with PLGF-1 and PIK3CA

Diseases associated with PLGF-1 active protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>383 publications with PLGF-1 and Cardiovascular Diseases
Inflammation Antibodies	>285 publications with PLGF-1 and Inflammation
Hypertension Antibodies	>194 publications with PLGF-1 and Hypertension
Disease Models, Animal Antibodies	>159 publications with PLGF-1 and Disease Models, Animal
Necrosis Antibodies	>154 publications with PLGF-1 and Necrosis
Lung Diseases Antibodies	>128 publications with PLGF-1 and Lung Diseases
Heart Diseases Antibodies	>127 publications with PLGF-1 and Heart Diseases
Atherosclerosis Antibodies	>93 publications with PLGF-1 and Atherosclerosis
Brain Diseases Antibodies	>72 publications with PLGF-1 and Brain Diseases
Kidney Diseases Antibodies	>69 publications with PLGF-1 and Kidney Diseases

Organs/Tissues associated with PLGF-1 active protein

Organ/Tissue Name	Pubmed Publications
Ovary Antibodies	>767 publications with PLGF-1 and Ovary
Uterus Antibodies	>732 publications with PLGF-1 and Uterus
Muscle Antibodies	>506 publications with PLGF-1 and Muscle
Heart Antibodies	>251 publications with PLGF-1 and Heart
Lung Antibodies	>238 publications with PLGF-1 and Lung
Kidney Antibodies	>212 publications with PLGF-1 and Kidney
Placenta Antibodies	>209 publications with PLGF-1 and Placenta
Embryonic Tissue Antibodies	>198 publications with PLGF-1 and Embryonic Tissue
Brain Antibodies	>195 publications with PLGF-1 and Brain
Liver Antibodies	>134 publications with PLGF-1 and Liver