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TFF2 (TFF-2) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS696172

The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF2 has been shown to inhibit gastrointestinal motility and gastric acid secretion.… More details

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Sample Manual Insert View PDF
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Material Safety Data Sheet View PDF
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Product Overview

Product Name
TFF2 (TFF-2), Active Protein
Full Product Name
Human TFF2
Product Gene Name
Product Synonym Names
Recombinant Human TFF-2
Sequence
AEKPSPCQC SRLSPHNRT NCGFPGITS DQCFDNGCC FDSSVTGVP WCFHPLPKQ ESDQCVMEV SDRRNCGYP GISPEECAS RKCCFSNFI FEVPWCFFP KSVEDCHY
Host
E Coli
Species Reactivity
Species Reactivity: Human
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Preparation and Storage
At -20 degree C
Molecular Weight
14,284 Da
OMIM
182590
3D Structure
ModBase 3D Structure for Q03403
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Assay #1: Determined by its ability to chemoattract human monocytes using a concentration range of 1.0-10.0 ug/ml. Assay #2: Determined by its ability to chemoattract human MCF-7 cells using a concentra

Product Categories/Family for TFF-2 active protein

Other Notes

Small volumes of TFF-2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TFF-2 purchase

MBS696172 is an active protein targeting TFF-2. Also known as Human TFF2. Reactive in Species Reactivity: Human. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TFF-2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Trefoil factor 2
NCBI Official Synonym Full Names
trefoil factor 2
NCBI Official Symbol
TFF2
NCBI Official Synonym Symbols
SP; SML1
UniProt Protein Name
Trefoil factor 2
UniProt Synonym Protein Names
Spasmolysin; Spasmolytic polypeptide; SP
UniProt Gene Name
TFF2
UniProt Synonym Gene Names
SML1; SP
UniProt Entry Name
TFF2_HUMAN
NCBI Protein Information
trefoil factor 2; spasmolysin; spasmolytic protein 1; spasmolytic polypeptide

NCBI Summary for TFF-2

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
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UniProt Comments for TFF-2

TFF2: Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: extracellular space

Molecular Function: protein binding; CXCR4 chemokine receptor binding

Biological Process: negative regulation of inflammatory response; positive regulation of cell proliferation; digestion; calcium-mediated signaling; negative regulation of macrophage activation; regulation of cell migration
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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