Mouse KC Active Protein – Cat# MBS696176

KC Mouse Active Protein

Name: KC Active Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS696176
Price: 180 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS696176

All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

KC, Active Protein

Full Product Name

Murine KC (CXCL1)

Product Gene Name

KC active protein

Product Synonym Gene Name

CXCL1

Product Synonym Names

Recombinant Murine KC (CXCL1)

Sequence

APIANELRC QCLQTMAGI HLKNIQSLK VLPSGPHCT QTEVIATLK NGREACLDP EAPLVQKIV QKMLKGVPK

Host

E Coli

Species Reactivity

Species Reactivity: Mouse
Cross Reactivity: Human, Rat

Purity/Purification

Above 98% as determined by SDS-PAGE Analysis.

Preparation and Storage

At -20 degree C

Molecular Weight

10,254 Da

3D Structure

ModBase 3D Structure for P12850

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Determined by its ability to chemoattract total human neutrophil population using a concentration range of 10.0-100.0 ng/ml.

Product Categories/Family for KC active protein

Innate Immunity; Angiogenesis; Neurosciences; Inflammation; Chemotaxis

Other Notes

Small volumes of KC active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KC purchase

MBS696176 is an active protein targeting KC. Also known as Murine KC (CXCL1). Reactive in Species Reactivity: Mouse
Cross Reactivity: Human, Rat. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for KC. It may not necessarily be applicable to this product.

NCBI GI #

121623

NCBI GeneID

14825

NCBI Accession #

P12850.1

UniProt Primary Accession #

P12850

UniProt Related Accession #

P12850

NCBI Official Full Name

Growth-regulated alpha protein

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 1

NCBI Official Symbol

Cxcl1

NCBI Official Synonym Symbols

KC; Fsp; N51; gro; Gro1; Mgsa; Scyb1

UniProt Protein Name

Growth-regulated alpha protein

UniProt Synonym Protein Names

C-X-C motif chemokine 1; Platelet-derived growth factor-inducible protein KC; Secretory protein N51Cleaved into the following chain:KC(5-72)Alternative name(s):Hematopoietic synergistic factor; HSF; KC-T

Protein Family

KCNQ1 downstream neighbor protein

UniProt Gene Name

Cxcl1

UniProt Synonym Gene Names

Gro; Gro1; Mgsa; Scyb1; HSF

UniProt Entry Name

GROA_MOUSE

NCBI Protein Information

growth-regulated alpha protein; KC/GR)-alpha; KC/GRO-alpha; GRO1 oncogene; alpha-chemokine; secretory protein N51; C-X-C motif chemokine 1; platelet-derived growth factor-inducible protein KC

NCBI Summary for KC

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013]

UniProt Comments for KC

CXCL2: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Cellular Component: extracellular space; cell; extracellular region; cytosol

Molecular Function: growth factor activity; chemokine activity; CXCR chemokine receptor binding; cytokine activity

Biological Process: neutrophil chemotaxis; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; positive regulation of superoxide release; response to molecule of bacterial origin; positive regulation of potassium ion transport; response to lipopolysaccharide; immune response; positive regulation of leukocyte chemotaxis; inflammatory response; acute inflammatory response; regulation of cell proliferation

Research Articles on KC

1. These studies suggest that modulation of CXCL1 levels in tissues and blood could reduce bacterial burden in sepsis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with KC active protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response (BioCarta) Pathway antibodies	Cytokines And Inflammatory Response (BioCarta) Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram

Diseases associated with KC active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>1146 publications with KC and Inflammation
Necrosis Antibodies	>557 publications with KC and Necrosis
Disease Models, Animal Antibodies	>414 publications with KC and Disease Models, Animal
Lung Diseases Antibodies	>325 publications with KC and Lung Diseases
Cardiovascular Diseases Antibodies	>190 publications with KC and Cardiovascular Diseases
Lung Injury Antibodies	>170 publications with KC and Lung Injury
Pneumonia Antibodies	>113 publications with KC and Pneumonia
Acute Lung Injury Antibodies	>97 publications with KC and Acute Lung Injury
Reperfusion Injury Antibodies	>97 publications with KC and Reperfusion Injury
Wounds and Injuries Antibodies	>95 publications with KC and Wounds and Injuries

Organs/Tissues associated with KC active protein

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>62 publications with KC and Connective Tissue
Embryonic Tissue Antibodies	>43 publications with KC and Embryonic Tissue
Spinal Cord Antibodies	>34 publications with KC and Spinal Cord
Adipose Tissue Antibodies	>23 publications with KC and Adipose Tissue
Ovary Antibodies	>17 publications with KC and Ovary
Mammary Gland Antibodies	>9 publications with KC and Mammary Gland
Extraembryonic Tissue Antibodies	>1 publications with KC and Extraembryonic Tissue
Testis Antibodies	>1 publications with KC and Testis