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BCA-1/ BLC (BCA1) Mouse Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS140714

Introduction: BCA-1 is a CXC chemokine that is highly expressed in thesecondary lymphoid organs, such as follicles of the spleen, lymph nodes, and Peyer's patches. CXCL13 promotes the migration of B lymphocytes (compared to T cells and macrophages), by… More details

$250 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
BCA-1/ BLC (BCA1), Active Protein
Full Product Name
Recombinant Mouse BCA-1/ BLC (CXCL13)
Product Gene Name
BCA1 active protein
Product Synonym Gene Name
mBCA1
Product Synonym Names
BCA 1 Mouse; BCA-1/BLC Mouse Recombinant (CXCL13); C-X-C motif chemokine 13; B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13; Cxcl13; Blc; Scyb13
Sequence
ILEAHYTNLK CRCSGVISTV VGLNIIDRIQ VTPPGNGCPK TEVVIWTKMK KVICVNPRAK WLQRLLRHVQ SKSLSSTPQA PVSKRRAA
Host
E Coli
Form/Format
The BCA1 protein was lyophilized from a 0.2?m filtered solution in Acetonitrile and TFA.
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Greater than 97.0% as determined by SDS-PAGE.
Preparation and Storage
Lyophilized BCA1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution BCA1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Molecular Weight
11,927 Da
3D Structure
ModBase 3D Structure for O55038
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
The ED50, as measured by its ability to chemoattract human CXCR5-transfected mouse BaF3 cells, is less than 2 ug/ml.
Solubility
It is recommended to reconstitute the lyophilized CXCL13 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Product Categories/Family for BCA1 active protein

Chemokines

Other Notes

Small volumes of BCA1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BCA1 purchase

MBS140714 is an active protein targeting BCA1. Also known as Recombinant Mouse BCA-1/ BLC (CXCL13). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BCA1. It may not necessarily be applicable to this product.

NCBI GI #
9256521
NCBI GeneID
55985
NCBI Accession #
NP_061354.1
UniProt Primary Accession #
O55038
UniProt Related Accession #
O55038
GenBank Nucleotide #
NM_018866.2
NCBI Official Full Name
C-X-C motif chemokine 13
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 13
NCBI Official Symbol
Cxcl13
NCBI Official Synonym Symbols
BLC; Angie; BCA-1; BLR1L; ANGIE2; Scyb13; 4631412M08Rik
UniProt Protein Name
C-X-C motif chemokine 13
UniProt Synonym Protein Names
B lymphocyte chemoattractant; CXC chemokine BLC; Small-inducible cytokine B13
UniProt Gene Name
Cxcl13
UniProt Synonym Gene Names
Blc; Scyb13
UniProt Entry Name
CXL13_MOUSE
NCBI Protein Information
C-X-C motif chemokine 13

UniProt Comments for BCA1

CXCL13: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Cellular Component: extracellular region; extracellular space

Molecular Function: CCR10 chemokine receptor binding; chemokine activity; CXCR3 chemokine receptor binding; CXCR5 chemokine receptor binding; fibroblast growth factor binding; heparin binding; protein heterodimerization activity; receptor agonist activity

Biological Process: cell surface receptor linked signal transduction; cell-cell signaling; defense response to bacterium; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; lymph node development; lymphocyte chemotaxis across high endothelial venule; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of integrin activation; positive regulation of leukocyte chemotaxis; regulation of cell proliferation; response to lipopolysaccharide
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BCA1 active protein

 Reference Product  PubMed Publications
 Cxcr5 active protein  >229 publications with BCA1 and Cxcr5
 Cxcl10 active protein  >72 publications with BCA1 and Cxcl10
 Ccr7 active protein  >59 publications with BCA1 and Ccr7
 Cxcl9 active protein  >40 publications with BCA1 and Cxcl9
 Ccl5 active protein  >35 publications with BCA1 and Ccl5
 Cxcr3 active protein  >32 publications with BCA1 and Cxcr3

Pathways associated with BCA1 active protein

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with BCA1 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >191 publications with BCA1 and Inflammation
 Necrosis Antibodies  >69 publications with BCA1 and Necrosis
 Disease Models, Animal Antibodies  >61 publications with BCA1 and Disease Models, Animal
 Carcinoma Antibodies  >36 publications with BCA1 and Carcinoma
 Lung Diseases Antibodies  >36 publications with BCA1 and Lung Diseases
 Brain Diseases Antibodies  >35 publications with BCA1 and Brain Diseases
 Vascular Diseases Antibodies  >25 publications with BCA1 and Vascular Diseases
 Hyperplasia Antibodies  >20 publications with BCA1 and Hyperplasia
 Kidney Diseases Antibodies  >20 publications with BCA1 and Kidney Diseases
 Recurrence Antibodies  >18 publications with BCA1 and Recurrence

Organs/Tissues associated with BCA1 active protein

 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >194 publications with BCA1 and Lymph Node
 Spleen Antibodies  >86 publications with BCA1 and Spleen
 Lung Antibodies  >50 publications with BCA1 and Lung
 Skin Antibodies  >44 publications with BCA1 and Skin
 Kidney Antibodies  >28 publications with BCA1 and Kidney
 Muscle Antibodies  >24 publications with BCA1 and Muscle
 Intestine Antibodies  >23 publications with BCA1 and Intestine
 Thymus Antibodies  >22 publications with BCA1 and Thymus
 Stomach Antibodies  >10 publications with BCA1 and Stomach
 Extraembryonic Tissue Antibodies  >1 publications with BCA1 and Extraembryonic Tissue
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