Remdesivir (GS-5734)

Remdesivir is a prodrug that metabolizes into its active form GS-441524, which interferes with the action of viral RNA polymerase and degrades viral RNA production. It is reported to exhibit antiviral activity against single stranded RNA viruses such as Ebola, Marburg, Hendra, and coronaviruses. It is currently being researched as a potential treatment for COVID-19.

Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., ... & Xiao, G. (2020). Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell research, 30(3), 269-271.
Gordon, C. J., Tchesnokov, E. P., Feng, J. Y., Porter, D. P., & Gotte, M. (2020). The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus. Journal of Biological Chemistry, jbc-AC120.
de Wit, E., Feldmann, F., Cronin, J., Jordan, R., Okumura, A., Thomas, T., ... & Feldmann, H. (2020). Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection. Proceedings of the National Academy of Sciences.

Small volumes of Remdesivir biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS696230 is a biochemical targeting Remdesivir.