CD127 Antibody – Rat Monoclonal

The A7R34 monoclonal antibody specifically reacts with the mouse CD127, the alpha subunit of the IL-7 receptor, expressed by immature B lymphocytes in the bone marrow, CD4-/CD8-, CD4+, and CD8+ thymocytes, and by mature T lymphocytes at low levels. Mature T cells express CD117 at low levels in the periphery.
The A7R34 antibody prevents the interaction between IL-7 and its receptor and the binding of mAb SB/199, which also recognizes mouse CD127.

Sudo, T., Nishikawa, S. A. T. O. M. I., Ohno, N. O. R. I. K. O., Akiyama, N. A. O. K. O., Tamakoshi, M. A. S. A. T. A. D. A., & Yoshida, H. I. S. A. H. I. R. O. (1993). Expression and function of the interleukin 7 receptor in murine lymphocytes. Proceedings of the National Academy of Sciences, 90(19), 9125-9129.
Hashi, H., Yoshida, H., Honda, K., Fraser, S., Kubo, H., Awane, M.,... & Nishikawa, S. I. (2001). Compartmentalization of Peyer's patch anlagen before lymphocyte entry. The Journal of Immunology, 166(6), 3702-3709.
Okuno, Y., Iwasaki, H., Huettner, C. S., Radomska, H. S., Gonzalez, D. A., Tenen, D. G., & Akashi, K. (2002). Differential regulation of the human and murine CD34 genes in hematopoietic stem cells. Proceedings of the National Academy of Sciences, 99(9), 6246-6251.

Small volumes of anti-CD127 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS697040 is an antibody targeting CD127. Also known as Anti-Mouse CD127 (IL-7Ra) APC. Reactive in Mouse. Host: Rat.