CD137 Antibody – Mouse Monoclonal

The 4B4 monoclonal antibody reacts with human CD137 (4-1BB), a type I membrane protein and member of the TNFR family. It is expressed on NK cells, T cells, dendritic cells, and mast cells and plays a role in T cell activation and proliferation.

Kienzle, G., & von Kempis, J. (2000). CD137 (ILA/4-1BB), expressed by primary human monocytes, induces monocyte activation and apoptosis of B lymphocytes. International immunology, 12(1), 73-82.
Lin, W., Voskens, C. J., Zhang, X., Schindler, D. G., Wood, A., Burch, E.,... & Wang, L. X. (2008). Fc-dependent expression of CD137 on human NK cells: insights into "agonistic" effects of anti-CD137 monoclonal antibodies. Blood, 112(3), 699-707.
Kim, K. M., Kim, H. W., Kim, J. O., Baek, K. M., Kim, J. G., & Kang, C. Y. (2002). Induction of 4?1BB (CD137) expression by DNA damaging agents in human T lymphocytes. Immunology, 107(4), 472-479.

Small volumes of anti-CD137 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS697044 is an antibody targeting CD137. Also known as Anti-Human CD137 (4-1BB) PE-Cyanine7. Reactive in Human. Host: Mouse.