CD197 Antibody – Rat Monoclonal

The 4B12 monoclonal antibody specifically reacts with mouse CD197 (CCR7), a seven-transmembrane G-protein-coupled glycoprotein. CD197 is a receptor thought to be a mediator of EBV effects on B lymphocytes. It is expressed on lymphoid tissue and is known to activate B and T lymphocytes and stimulate dendritic cell maturation. It often serves as a homing receptor that is used to guide various cell types to and within lymphoid tissue. The 4B12 antibody is not reported to block the binding of CCL21 to CCR7. We recommend that the cell staining done with this antibody be conducted at 37 degree C.

Britschgi, M. R., Link, A., Lissandrin, T. K. A., & Luther, S. A. (2008). Dynamic modulation of CCR7 expression and function on naive T lymphocytes in vivo. The Journal of Immunology, 181(11), 7681-7688.
Ohl, L., Mohaupt, M., Czeloth, N., Hintzen, G., Kiafard, Z., Zwirner, J.,... & Förster, R. (2004). CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity, 21(2), 279-288.
Ritter, U., Wiede, F., Mielenz, D., Kiafard, Z., Zwirner, J., & Körner, H. (2004). Analysis of the CCR7 expression on murine bone marrow-derived and spleen dendritic cells. Journal of leukocyte biology, 76(2), 472-476.

Small volumes of anti-CD197 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS697050 is an antibody targeting CD197. Also known as Anti-Mouse CD197 (CCR7) PE. Reactive in Mouse. Host: Rat.