CD252 Antibody – Rat Monoclonal

The RM134L monoclonal antibody specifically reacts with mouse CD252, a TNF/NGF superfamily member present on activated B lymphocytes and antigen-presenting cells. On activated B cells it enhances immunoglobulin secretion and cell proliferation. CD252 is also known as the OX-40 ligand and interacts with the OX-40 antigen found on the surface of activated T cells. The RML134L is reported to block the costimulatory activity of OX-40L.

Stüber, E., Neurath, M., Calderhead, D., Perry Fell, H., & Strober, W. (1995). Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells. Immunity,2(5), 507-521.
Akiba, H., Oshima, H., Takeda, K., Atsuta, M., Nakano, H., Nakajima, A.,... & Okumura, K. (1999). CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. The Journal of Immunology, 162(12), 7058-7066.
Calderhead, D. M., Buhlmann, J. E., Van den Eertwegh, A. J., Claassen, E., Noelle, R. J., & Fell, H. P. (1993). Cloning of mouse Ox40: a T cell activation marker that may mediate TB cell interactions. The Journal of Immunology,151(10), 5261-5271.

Small volumes of anti-CD252 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS697057 is an antibody targeting CD252. Also known as Anti-Mouse CD252 (OX40L) Biotin. Reactive in Mouse. Host: Rat.