CD272 Antibody – Mouse Monoclonal

The MIH26 monoclonal antibody specifically reacts with human CD272, the human and B and T lymphocyte attenuator (BTLA). It is expressed on macrophage, dendritic, NK, NKT, B, and T cells. CD272 (BTLA) is an inhibitory receptor that inhibits T cell proliferation after binding with its ligand, the herpes virus entry mediator (HVEM). It is in the CD28-like family of receptors and is structurally similar to CTLA-4 and PD-1.

Otsuki, N., Kamimura, Y., Hashiguchi, M., & Azuma, M. (2006). Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells. Biochemical and biophysical research communications, 344(4), 1121-1127.
Watanabe, N., Gavrieli, M., Sedy, J. R., Yang, J., Fallarino, F., Loftin, S. K.,... & Murphy, K. M. (2003). BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nature immunology, 4(7), 670-679.
Sedy, J. R., Gavrieli, M., Potter, K. G., Hurchla, M. A., Lindsley, R. C., Hildner, K.,... & Murphy, K. M. (2005). B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nature immunology, 6(1), 90-98.

Small volumes of anti-CD272 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS697059 is an antibody targeting CD272. Also known as Anti-Human CD272 (BTLA) Biotin. Reactive in Human. Host: Mouse.