CD223 Antibody – Mouse Monoclonal

The 3DS223H monoclonal antibody recognized human CD223, a 70 kDa glycoprotein that is also known as the Lymphocyte Activation Gene 3 (LAG-3). CD223 is an immune checkpoint receptor in the Ig superfamily and its main ligand is MHC class II, which it binds with higher affinity than CD4. It is reported to play a role in Treg suppressive activity and is involved in the maturation and activation of dendritic cells

Anvari, S., Grimbergen, A., Davis, C. M., & Makedonas, G. (2017). Protein transport inhibitors downregulate the expression of LAG-3 on regulatory T cells. Journal of immunological methods, 447, 47-51.
Jiang, Z., Jiang, X., Chen, S., Lai, Y., Wei, X., Li, B.,... & Liu, Q. (2017). Anti-GPC3-CAR T cells suppress the growth of tumor cells in patient-derived xenografts of hepatocellular carcinoma. Frontiers in immunology, 7, 690.
Long, A. H., Highfill, S. L., Cui, Y., Smith, J. P., Walker, A. J., Ramakrishna, S.,... & Mackall, C. L. (2016). Reduction of MDSCs with all-trans retinoic acid improves CAR therapy efficacy for sarcomas. Cancer immunology research, canimm-0230.

Small volumes of anti-CD223 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS697063 is an antibody targeting CD223. Also known as Anti-Human CD223 (LAG3) FITC. Reactive in Human. Host: Mouse.