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TGF-Beta3 ELISA Kit for Human

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS697368

The three mammalian isoforms of TGF-beta, TGF-beta1, beta2, and beta3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well… More details

$655 / 1 Kit +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TGF-beta3, ELISA Kit
Full Product Name
Human TGF-beta3 Pre-Coated ELISA Kit
Product Gene Name
TGF-beta3 elisa kit
Species Reactivity
Human
Assay Type
Solid Phase Sandwich ELISA: 96-Well Strip Plate
Detection Range
31.2pg/ml-2000pg/ml
Sensitivity
<10pg/ml
Specificity
Natural and recombinant Human TGF-beta3
Preparation and Storage
Store the unopened product at 2-8 degree C.
Molecular Weight
47,328 Da
Chromosome Location
Chromosome: 14; NC_000014.8 (76424442..76448092, complement). Location: 14q24
OMIM
107970
3D Structure
ModBase 3D Structure for P10600
Components
Anti-Human TGF-beta3 Pre-coated 96-well strip microplate
Human TGF-beta3 Standard
Human TGF-beta3 Biotinylated antibody (100x)
Avidin-Biotin-Peroxidase Complex (100x)
Sample Diluent
Antibody Diluent
Avidin-Biotin-Peroxidase Diluent
Wash Buffer Concentrate (Powder for 1000mL)
Color Developing Reagent
Stop Solution
Plate Sealers
Interference
No detectable cross-reactivity with other relevant proteins

Typical Testing Data/Standard Curve (for reference only) of TGF-beta3 elisa kit

Human TGF-beta3 ELISA Kit – Cat# MBS697368

Other Notes

Small volumes of TGF-beta3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TGF-beta3 purchase

MBS697368 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the TGF-beta3, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TGF-beta3. The ELISA analytical biochemical technique of the MBS697368 kit is based on TGF-beta3 antibody-TGF-beta3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TGF-beta3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TGF-beta3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for TGF-beta3. It may not necessarily be applicable to this product.

NCBI GI #
4507465
NCBI GeneID
7043
NCBI Accession #
NP_003230.1
UniProt Primary Accession #
P10600
UniProt Related Accession #
P10600
GenBank Nucleotide #
NM_003239.2
NCBI Official Full Name
transforming growth factor beta-3 preproprotein
NCBI Official Synonym Full Names
transforming growth factor, beta 3
NCBI Official Symbol
TGFB3
NCBI Official Synonym Symbols
ARVD; TGF-beta3
UniProt Protein Name
Transforming growth factor beta-3
UniProt Gene Name
TGFB3
UniProt Synonym Gene Names
TGF-beta-3; LAP
UniProt Entry Name
TGFB3_HUMAN
NCBI Protein Information
transforming growth factor beta-3; TGF-beta-3

NCBI Summary for TGF-beta3

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]

UniProt Comments for TGF-beta3

TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family.

Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Ligand, receptor tyrosine kinase; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: extracellular matrix; extracellular space; cell surface; cell soma; T-tubule; extracellular region; plasma membrane; nucleus

Molecular Function: identical protein binding; protein binding; growth factor activity; transforming growth factor beta binding; protein heterodimerization activity; punt binding; cytokine activity

Biological Process: extracellular matrix organization and biogenesis; positive regulation of apoptosis; activation of MAPK activity; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; female pregnancy; SMAD protein nuclear translocation; palate development; odontogenesis; regulation of apoptosis; negative regulation of cell proliferation; platelet degranulation; mammary gland development; transforming growth factor beta receptor signaling pathway; salivary gland morphogenesis; embryonic neurocranium morphogenesis; negative regulation of neuron apoptosis; cell growth; inner ear development; aging; positive regulation of filopodium formation; uterine wall breakdown; intercellular junction assembly and maintenance; platelet activation; in utero embryonic development; positive regulation of bone mineralization; regulation of cell proliferation; positive regulation of protein secretion; gut development; negative regulation of DNA replication; response to estrogen stimulus; regulation of MAPKKK cascade; positive regulation of cell division; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; response to progesterone stimulus; blood coagulation; negative regulation of transforming growth factor beta receptor signaling pathway; alveolus development; positive regulation of DNA replication

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome
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Research Articles on TGF-beta3

1. These results highlight TGFbeta/5-HT signaling as a potent mechanism for control of biomechanical remodeling of atrioventricular cushions during development.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TGF-beta3 elisa kit

 Reference Product  PubMed Publications
 TGFB2 elisa kit  >534 publications with TGF-beta3 and TGFB2
 ENG elisa kit  >84 publications with TGF-beta3 and ENG
 TGFBR3 elisa kit  >23 publications with TGF-beta3 and TGFBR3
 CTGF elisa kit  >19 publications with TGF-beta3 and CTGF
 TGFBR2 elisa kit  >7 publications with TGF-beta3 and TGFBR2
 TGFBR1 elisa kit  >7 publications with TGF-beta3 and TGFBR1
 LTBP3 elisa kit  >1 publications with TGF-beta3 and LTBP3
 FMOD elisa kit  >1 publications with TGF-beta3 and FMOD
 ACVRL1 elisa kit  >1 publications with TGF-beta3 and ACVRL1

Pathways associated with TGF-beta3 elisa kit

 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Chronic Myeloid Leukemia Pathway antibodies  Chronic Myeloid Leukemia Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram

Diseases associated with TGF-beta3 elisa kit

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >175 publications with TGF-beta3 and Fibrosis
 Cleft Palate Antibodies  >91 publications with TGF-beta3 and Cleft Palate
 Disease Models, Animal Antibodies  >87 publications with TGF-beta3 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >79 publications with TGF-beta3 and Cardiovascular Diseases
 Inflammation Antibodies  >63 publications with TGF-beta3 and Inflammation
 Necrosis Antibodies  >57 publications with TGF-beta3 and Necrosis
 Heart Diseases Antibodies  >49 publications with TGF-beta3 and Heart Diseases
 Breast Neoplasms Antibodies  >35 publications with TGF-beta3 and Breast Neoplasms
 Lung Diseases Antibodies  >33 publications with TGF-beta3 and Lung Diseases
 Drug Toxicity Antibodies  >26 publications with TGF-beta3 and Drug Toxicity

Organs/Tissues associated with TGF-beta3 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >305 publications with TGF-beta3 and Bone
 Connective Tissue Antibodies  >208 publications with TGF-beta3 and Connective Tissue
 Embryonic Tissue Antibodies  >129 publications with TGF-beta3 and Embryonic Tissue
 Mouth Antibodies  >109 publications with TGF-beta3 and Mouth
 Bone Marrow Antibodies  >100 publications with TGF-beta3 and Bone Marrow
 Heart Antibodies  >76 publications with TGF-beta3 and Heart
 Lung Antibodies  >69 publications with TGF-beta3 and Lung
 Brain Antibodies  >63 publications with TGF-beta3 and Brain
 Eye Antibodies  >57 publications with TGF-beta3 and Eye
 Liver Antibodies  >50 publications with TGF-beta3 and Liver
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