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Cartilage Oligomeric Matrix (COMP) ELISA Kit for Rat

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS700024

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to COMP. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated polyclonal antibody preparation… More details

$295 / 24-Strip-Wells (LIMIT 1) +1 FREE 8GB USB

Product Documentation

PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
cartilage oligomeric matrix protein (COMP), ELISA Kit
Full Product Name
Rat cartilage oligomeric matrix protein, COMP ELISA Kit
Product Gene Name
COMP elisa kit
Product Synonym Names
Rat cartilage oligomeric matrix protein; COMP ELISA Kit; EDM1; EPD1; MED; MGC131819; MGC149768; PSACH; THBS5; cartilage oligomeric matrix protein (pseudoachondroplasia; epiphyseal dysplasia 1; multiple) ; cartilage oligomeric matrix protein (pseudoachondropl; cartilage oligomeric matrix protein
Species Reactivity
Rat
Samples
Serum, plasma, tissue homogenates
Detection Range
0.78 ng/ml-50 ng/ml
Sensitivity
0.195 ng/ml
Specificity
This assay has high sensitivity and excellent specificity for detection of Rat COMP. No significant cross-reactivity or interference between Rat COMP and analogues was observed.
Preparation and Storage
Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
Intra-assay Precision
Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.
Molecular Weight
82,664 Da
3D Structure
ModBase 3D Structure for P35444
Detection Wavelength
450 nm
Sample Volume
50-100ul
Protein Biological Process 1
Apoptosis/Autophagy
Protein Biological Process 3
Apoptosis
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Typical Testing Data/Standard Curve (for reference only) of COMP elisa kit

Rat COMP ELISA Kit – Cat# MBS700024

Other Notes

Small volumes of COMP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COMP purchase

MBS700024 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the cartilage oligomeric matrix protein (COMP) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing COMP. The ELISA analytical biochemical technique of the MBS700024 kit is based on COMP antibody-COMP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect COMP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, COMP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for COMP. It may not necessarily be applicable to this product.

NCBI GI #
6978679
NCBI GeneID
25304
NCBI Accession #
NP_036966.1
UniProt Primary Accession #
P35444
UniProt Related Accession #
P35444
GenBank Nucleotide #
NM_012834.1
NCBI Official Full Name
cartilage oligomeric matrix protein
NCBI Official Synonym Full Names
cartilage oligomeric matrix protein
NCBI Official Symbol
Comp
UniProt Protein Name
Cartilage oligomeric matrix protein
Protein Family
Cartilage oligomeric matrix protein
UniProt Gene Name
Comp
UniProt Synonym Gene Names
COMP
UniProt Entry Name
COMP_RAT
NCBI Protein Information
cartilage oligomeric matrix protein

NCBI Summary for COMP

extracellular matrix protein that interacts with fibronectin and may play a role in extracellular matrix assembly and molecular interactions [RGD, Feb 2006]

UniProt Comments for COMP

Function: May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.1 PublicationManual assertion based on experiment in:Ref.2

Cofactor: Binds 11-14 calcium ions per subunit
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Research Articles on COMP

1. results suggest the potential importance of COMP-Ang1 as a new therapy for impaired bone formation that is associated with diabetes and advanced age

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with COMP elisa kit

 Reference Product  PubMed Publications
 FLNA elisa kit  >12 publications with COMP and FLNA

Pathways associated with COMP elisa kit

 Products by Pathway  Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram

Diseases associated with COMP elisa kit

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >1718 publications with COMP and Disease Models, Animal
 Inflammation Antibodies  >1160 publications with COMP and Inflammation
 Necrosis Antibodies  >1021 publications with COMP and Necrosis
 Nerve Degeneration Antibodies  >956 publications with COMP and Nerve Degeneration
 Liver Diseases Antibodies  >878 publications with COMP and Liver Diseases
 Kidney Diseases Antibodies  >688 publications with COMP and Kidney Diseases
 Hypertension Antibodies  >650 publications with COMP and Hypertension
 Fatty Liver Antibodies  >604 publications with COMP and Fatty Liver
 Weight Loss Antibodies  >566 publications with COMP and Weight Loss
 Weight Gain Antibodies  >512 publications with COMP and Weight Gain

Organs/Tissues associated with COMP elisa kit

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >13 publications with COMP and Bone
 Connective Tissue Antibodies  >4 publications with COMP and Connective Tissue
 Heart Antibodies  >3 publications with COMP and Heart
 Muscle Antibodies  >3 publications with COMP and Muscle
 Brain Antibodies  >3 publications with COMP and Brain
 Vascular Antibodies  >2 publications with COMP and Vascular
 Embryonic Tissue Antibodies  >2 publications with COMP and Embryonic Tissue
 Ear Antibodies  >1 publications with COMP and Ear
 Kidney Antibodies  >1 publications with COMP and Kidney
 Umbilical Cord Antibodies  >1 publications with COMP and Umbilical Cord
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