Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) ELISA Kit for Human

Name: Human CYR61 ELISA Kit; Cysteine-Rich, Angiogenic Inducer, 61; MyBioSource
Brand: MyBioSource
SKU: MBS700945
Price: 295 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS700945

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for CyPB has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any CyPB present is bound by the… More details

$295 / 24-Strip-Wells (LIMIT 1) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

cysteine-rich, angiogenic inducer, 61 (CYR61), ELISA Kit

Full Product Name

Human cysteine-rich 61, Cyr61/CCN1 ELISA Kit

Product Gene Name

CYR61 elisa kit

Product Synonym Names

Human cysteine-rich 61 (Cyr61/CCN1) ELISA Kit; CCN1; GIG1; IGFBP10; cysteine-rich heparin-binding protein 61; cysteine-rich; anigogenic inducer; 61; cysteine-rich; angiogenic inducer; 61

Species Reactivity

Human

Assay Type

Quantitative Sandwich

Samples

Serum, Plasma, Cell Lysates, Tissue Homogenates

Detection Range

31.25 pg/ml-2000 pg/ml

Sensitivity

7.81 pg/ml.

Specificity

This assay has high sensitivity and excellent specificity for detection of human CyPB. No significant cross-reactivity or interference between human CyPB and analogues was observed.

Preparation and Storage

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Inter-assay Precision

Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

Intra-assay Precision

Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess

Molecular Weight

42,027 Da

OMIM

602369

3D Structure

ModBase 3D Structure for O00622

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CYR61 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CYR61 purchase

MBS700945 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the cysteine-rich, angiogenic inducer, 61 (CYR61) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CYR61. The ELISA analytical biochemical technique of the MBS700945 kit is based on CYR61 antibody-CYR61 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CYR61 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CYR61. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for CYR61. It may not necessarily be applicable to this product.

NCBI GI #

31542331

NCBI GeneID

3491

NCBI Accession #

NP_001545.2

UniProt Primary Accession #

O00622

UniProt Secondary Accession #

O14934; O43775; Q9BZL7

UniProt Related Accession #

O00622

GenBank Nucleotide #

NM_001554.4

NCBI Official Full Name

protein CYR61

NCBI Official Synonym Full Names

cysteine-rich, angiogenic inducer, 61

NCBI Official Symbol

CYR61

NCBI Official Synonym Symbols

CCN1; GIG1; IGFBP10

UniProt Protein Name

Protein CYR61

UniProt Synonym Protein Names

CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein GIG1

Protein Family

Protein

UniProt Gene Name

CYR61

UniProt Synonym Gene Names

CCN1; GIG1; IGFBP10; IBP-10; IGF-binding protein 10; IGFBP-10

UniProt Entry Name

CYR61_HUMAN

NCBI Protein Information

protein CYR61; IBP-10; IGFBP-10; CCN family member 1; IGF-binding protein 10; cysteine-rich, anigogenic inducer, 61; cysteine-rich heparin-binding protein 61; insulin-like growth factor-binding protein 10

NCBI Summary for CYR61

The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

UniProt Comments for CYR61

Function: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.1 PublicationManual assertion based on experiment in:Ref.10

Research Articles on CYR61

1. Our results suggest that CCN1 has a role in the development of intraepithelial breast carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CYR61 elisa kit

Reference Product	PubMed Publications
JUN elisa kit	>84 publications with CYR61 and JUN
FOS elisa kit	>19 publications with CYR61 and FOS
CTNNB1 elisa kit	>11 publications with CYR61 and CTNNB1
SRF elisa kit	>4 publications with CYR61 and SRF
MKL1 elisa kit	>3 publications with CYR61 and MKL1
ITGB2 elisa kit	>1 publications with CYR61 and ITGB2
ITGAV elisa kit	>1 publications with CYR61 and ITGAV

Pathways associated with CYR61 elisa kit

Products by Pathway	Pathway Diagram
Hypertrophy Model Pathway antibodies	Hypertrophy Model Pathway Diagram
Oncostatin M Signaling Pathway antibodies	Oncostatin M Signaling Pathway Diagram
Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies	Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
RhoA Signaling Pathway antibodies	RhoA Signaling Pathway Diagram
Amb2 Integrin Signaling Pathway antibodies	Amb2 Integrin Signaling Pathway Diagram

Diseases associated with CYR61 elisa kit

Disease Name	Pubmed Publications
Carcinoma Antibodies	>78 publications with CYR61 and Carcinoma
Inflammation Antibodies	>49 publications with CYR61 and Inflammation
Disease Models, Animal Antibodies	>40 publications with CYR61 and Disease Models, Animal
Breast Neoplasms Antibodies	>38 publications with CYR61 and Breast Neoplasms
Adenocarcinoma Antibodies	>37 publications with CYR61 and Adenocarcinoma
Neoplasm Metastasis Antibodies	>36 publications with CYR61 and Neoplasm Metastasis
Fibrosis Antibodies	>34 publications with CYR61 and Fibrosis
Nervous System Diseases Antibodies	>28 publications with CYR61 and Nervous System Diseases
Necrosis Antibodies	>24 publications with CYR61 and Necrosis
Brain Diseases Antibodies	>22 publications with CYR61 and Brain Diseases

Organs/Tissues associated with CYR61 elisa kit

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>148 publications with CYR61 and Connective Tissue
Vascular Antibodies	>101 publications with CYR61 and Vascular
Muscle Antibodies	>59 publications with CYR61 and Muscle
Bone Antibodies	>59 publications with CYR61 and Bone
Embryonic Tissue Antibodies	>47 publications with CYR61 and Embryonic Tissue
Lung Antibodies	>35 publications with CYR61 and Lung
Brain Antibodies	>33 publications with CYR61 and Brain
Prostate Antibodies	>25 publications with CYR61 and Prostate
Kidney Antibodies	>22 publications with CYR61 and Kidney
Skin Antibodies	>22 publications with CYR61 and Skin