Ficolin (Collagen/Fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3) ELISA Kit for Human

Name: Human FCN3 ELISA Kit; MyBioSource
Brand: MyBioSource
SKU: MBS701581
Price: 295 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS701581

Principle of the Assay||This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for FCN3 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any FCN3 present is bound by the… More details

$295 / 24-Strip-Wells (LIMIT 1) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen) (FCN3), ELISA Kit

Full Product Name

Human Ficolin 3, FCN3 ELISA Kit

Product Gene Name

FCN3 elisa kit

Product Synonym Names

Human Ficolin 3 (FCN3) ELISA Kit; FCNH; HAKA1; MGC22543; H-ficolin; collagen/fibrinogen domain-containing lectin 3 p35; collagen/fibrinogen domain-containing protein 3; ficolin 3; ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

Species Reactivity

Human

Assay Type

Sandwich

Samples

Serum, plasma, cell culture supernates, tissue homogenates.

Detection Range

7.8 ng/ml -500 ng/ml.

Sensitivity

1.95 ng/ml.

Specificity

This assay has high sensitivity and excellent specificity for detection of human FCN3. No significant cross-reactivity or interference between human FCN3 and analogues was observed.

Preparation and Storage

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Inter-assay Precision

Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.

Intra-assay Precision

Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.

Molecular Weight

32,903 Da

OMIM

gene 613860

3D Structure

ModBase 3D Structure for O75636

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of FCN3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FCN3 purchase

MBS701581 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen) (FCN3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FCN3. The ELISA analytical biochemical technique of the MBS701581 kit is based on FCN3 antibody-FCN3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FCN3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FCN3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for FCN3. It may not necessarily be applicable to this product.

NCBI GI #

27754776

NCBI GeneID

8547

NCBI Accession #

NP_003656.2

UniProt Primary Accession #

O75636

UniProt Secondary Accession #

Q6IBJ5; Q8WW86

UniProt Related Accession #

O75636

GenBank Nucleotide #

NM_003665.2

NCBI Official Full Name

ficolin-3 isoform 1

NCBI Official Synonym Full Names

ficolin (collagen/fibrinogen domain containing) 3

NCBI Official Symbol

FCN3

NCBI Official Synonym Symbols

FCNH; HAKA1

UniProt Protein Name

Ficolin-3

UniProt Synonym Protein Names

Collagen/fibrinogen domain-containing lectin 3 p35; Collagen/fibrinogen domain-containing protein 3; Hakata antigen

Protein Family

Ficolin

UniProt Gene Name

FCN3

UniProt Synonym Gene Names

FCNH; HAKA1

UniProt Entry Name

FCN3_HUMAN

NCBI Protein Information

ficolin-3; H-ficolin; ficolin 3; collagen/fibrinogen domain-containing protein 3; collagen/fibrinogen domain-containing lectin 3 p35; ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

NCBI Summary for FCN3

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]

UniProt Comments for FCN3

Function: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.1 PublicationManual assertion based on experiment in:Ref.9

Research Articles on FCN3

1. Data show that the expression of ficolin-3(FCN3) in ovarian cancer (OC) was inversely correlated with serum ficolin-3 and lower in comparison with controls.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FCN3 elisa kit

Reference Product	PubMed Publications
MASP2 elisa kit	>11 publications with FCN3 and MASP2
MASP1 elisa kit	>9 publications with FCN3 and MASP1
MBL2 elisa kit	>4 publications with FCN3 and MBL2
C1R elisa kit	>1 publications with FCN3 and C1R
C1S elisa kit	>1 publications with FCN3 and C1S

Pathways associated with FCN3 elisa kit

Products by Pathway	Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Creation Of C4 And C2 Activators Pathway antibodies	Creation Of C4 And C2 Activators Pathway Diagram
Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway antibodies	Ficolins Bind To Repetitive Carbohydrate Structures On The Target Cell Surface Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Initial Triggering Of Complement Pathway antibodies	Initial Triggering Of Complement Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Lectin Pathway Of Complement Activation antibodies	Lectin Pathway Of Complement Activation Diagram

Diseases associated with FCN3 elisa kit

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>7 publications with FCN3 and Cardiovascular Diseases
Disease Susceptibility Antibodies	>6 publications with FCN3 and Disease Susceptibility
Respiratory Tract Diseases Antibodies	>4 publications with FCN3 and Respiratory Tract Diseases
Inflammation Antibodies	>4 publications with FCN3 and Inflammation
Leukocyte Disorders Antibodies	>2 publications with FCN3 and Leukocyte Disorders
Myocardial Infarction Antibodies	>2 publications with FCN3 and Myocardial Infarction
Carcinoma Antibodies	>2 publications with FCN3 and Carcinoma
Pneumonia Antibodies	>1 publications with FCN3 and Pneumonia
Hypersensitivity Antibodies	>1 publications with FCN3 and Hypersensitivity
Lung Diseases Antibodies	>1 publications with FCN3 and Lung Diseases

Organs/Tissues associated with FCN3 elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>17 publications with FCN3 and Blood
Liver Antibodies	>4 publications with FCN3 and Liver
Lung Antibodies	>4 publications with FCN3 and Lung
Eye Antibodies	>1 publications with FCN3 and Eye
Kidney Antibodies	>1 publications with FCN3 and Kidney