Interleukin 1 Receptor Antagonist (IL1RN) ELISA Kit for Human

Name: Human IL1RN ELISA Kit; Interleukin 1 Receptor Antagonist; MyBioSource
Brand: MyBioSource
SKU: MBS701989
Price: 295 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS701989

MBS701989 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the interleukin 1 receptor antagonist (IL1RN) ELISA Kit target analytes in biological samples. The concentration gradients of the… More details

$295 / 24-Strip-Wells (LIMIT 1) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

interleukin 1 receptor antagonist (IL1RN), ELISA Kit

Full Product Name

Human Interleukin 1 receptor antagonist, IL-1ra ELISA Kit

Product Gene Name

IL1RN elisa kit

Product Synonym Names

Human Interleukin 1 receptor antagonist; IL-1ra ELISA kit; DIRA; ICIL-1RA; IL-1ra3; IL1F3; IL1RA; IRAP; MGC10430; MVCD4; IL1RN (IL1F3) ; OTTHUMP00000203730; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1r; interleukin 1 receptor antagonist

Species Reactivity

Human

Samples

Serum, plasma, cell culture supernates, tissue homogenates

Detection Range

78 pg/ml-5000 pg/ml

Sensitivity

19.5 pg/ml

Specificity

This assay has high sensitivity and excellent specificity for detection of Human IL1RN. No significant cross-reactivity or interference between Human IL1RN and analogues was observed.

Preparation and Storage

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Intra-assay Precision

Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.

Molecular Weight

20,055 Da

OMIM

612852

3D Structure

ModBase 3D Structure for P18510

Detection Wavelength

450 nm

Sample Volume

50-100ul

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of IL1RN elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IL1RN. It may not necessarily be applicable to this product.

NCBI GI #

10835147

NCBI GeneID

3557

NCBI Accession #

NP_000568.1

UniProt Primary Accession #

P18510

UniProt Secondary Accession #

Q14628; Q53SC2; Q7RTZ4; Q96GD6; Q9UPC0; A8K4G1

UniProt Related Accession #

P18510

GenBank Nucleotide #

NM_000577.4

NCBI Official Full Name

interleukin-1 receptor antagonist protein isoform 3

NCBI Official Synonym Full Names

interleukin 1 receptor antagonist

NCBI Official Symbol

IL1RN

NCBI Official Synonym Symbols

DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA

UniProt Protein Name

Interleukin-1 receptor antagonist protein

UniProt Synonym Protein Names

ICIL-1RA; IL1 inhibitor; INN: Anakinra

Protein Family

Interleukin-1 receptor antagonist protein

UniProt Gene Name

IL1RN

UniProt Synonym Gene Names

IL1F3; IL1RA; IL-1RN; IL-1ra; IRAP

UniProt Entry Name

IL1RA_HUMAN

NCBI Protein Information

interleukin-1 receptor antagonist protein; IL1 inhibitor; IL1RN (IL1F3); type II interleukin-1 receptor antagonist; intracellular IL-1 receptor antagonist type II; intracellular interleukin-1 receptor antagonist (icIL-1ra)

NCBI Summary for IL1RN

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

UniProt Comments for IL1RN

Function: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.1 PublicationManual assertion based on experiment in:Ref.17

Research Articles on IL1RN

1. The association between allele 1 of IL-1 RN VNTR, T allele of IL1B-511 and C allele of IL1-B +3953 polymorphisms seems to predispose to the synthesis of citrullinated antipeptide antibodies(ACPA) and occurrence of ACPA positive rheumatoid arthritis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL1RN elisa kit

Reference Product	PubMed Publications
IL1A elisa kit	>89 publications with IL1RN and IL1A
IL4 elisa kit	>24 publications with IL1RN and IL4
IL8 elisa kit	>23 publications with IL1RN and IL8
IL1R1 elisa kit	>18 publications with IL1RN and IL1R1
MMP3 elisa kit	>5 publications with IL1RN and MMP3
IL1R2 elisa kit	>5 publications with IL1RN and IL1R2
IL1RL2 elisa kit	>2 publications with IL1RN and IL1RL2
SELE elisa kit	>1 publications with IL1RN and SELE

Pathways associated with IL1RN elisa kit

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
IL-1 Signaling Pathway antibodies	IL-1 Signaling Pathway Diagram
IL1-mediated Signaling Events Pathway antibodies	IL1-mediated Signaling Events Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Interleukin-1 Signaling Pathway antibodies	Interleukin-1 Signaling Pathway Diagram
Leptin Signaling Pathway antibodies	Leptin Signaling Pathway Diagram
SIDS Susceptibility Pathways antibodies	SIDS Susceptibility Pathways Diagram
Signaling By Interleukins Pathway antibodies	Signaling By Interleukins Pathway Diagram

Diseases associated with IL1RN elisa kit

Disease Name	Pubmed Publications
Necrosis Antibodies	>773 publications with IL1RN and Necrosis
Inflammation Antibodies	>686 publications with IL1RN and Inflammation
Arthritis, Rheumatoid Antibodies	>301 publications with IL1RN and Arthritis, Rheumatoid
Cardiovascular Diseases Antibodies	>188 publications with IL1RN and Cardiovascular Diseases
Disease Models, Animal Antibodies	>164 publications with IL1RN and Disease Models, Animal
Skin Diseases Antibodies	>123 publications with IL1RN and Skin Diseases
Lung Diseases Antibodies	>109 publications with IL1RN and Lung Diseases
Pain Antibodies	>81 publications with IL1RN and Pain
Kidney Diseases Antibodies	>79 publications with IL1RN and Kidney Diseases
Heart Diseases Antibodies	>74 publications with IL1RN and Heart Diseases

Organs/Tissues associated with IL1RN elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1431 publications with IL1RN and Blood
Brain Antibodies	>322 publications with IL1RN and Brain
Skin Antibodies	>183 publications with IL1RN and Skin
Liver Antibodies	>149 publications with IL1RN and Liver
Lung Antibodies	>147 publications with IL1RN and Lung
Heart Antibodies	>112 publications with IL1RN and Heart
Eye Antibodies	>70 publications with IL1RN and Eye
Spleen Antibodies	>62 publications with IL1RN and Spleen
Pancreas Antibodies	>51 publications with IL1RN and Pancreas
Intestine Antibodies	>50 publications with IL1RN and Intestine