Mannose Receptor, Mr (MR) ELISA Kit for Human

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Apr 2011]

Function: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.

Subcellular location: Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein Ref.11.

Polymorphism: Genetic variations in MRC1 may influence susceptibility or resistance to leprosy in some populations. Particularly, Gly-396 seems to be a risk factor for leprosy when associated with Ala-399 and Phe-407.

Miscellaneous: CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.

Sequence similarities: Contains 8 C-type lectin domains.Contains 1 fibronectin type-II domain.Contains 1 ricin B-type lectin domain.

Sequence caution: The sequence CAH70733.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAH70872.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAH71176.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI15339.1 differs from that shown. Reason: Erroneous gene model prediction.