Ecto-NOX Disulfide-Thiol Exchanger 2 (ENOX2) Antibody – Rabbit Polyclonal

This gene is a tumor-specific member of the ECTO-NOX family of genes that encode cell surface NADH oxidases. The encoded protein has two enzymatic activities: catalysis of hydroquinone or NADH oxidation, and protein disulfide interchange. The protein also displays prion-like properties. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

ENOX2: May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide- thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. Belongs to the ENOX family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; EC 1.-.-.-; Cytoskeletal; Cell surface

Chromosomal Location of Human Ortholog: Xq25

Cellular Component: extracellular space; cytosol; external side of plasma membrane

Molecular Function: nucleic acid binding; nucleotide binding; protein disulfide oxidoreductase activity

Biological Process: regulation of growth; cell growth; ultradian rhythm