N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 1 (NDST1) Antibody – Rabbit Polyclonal

This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. The encoded protein catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to nitrogen of glucosamine in heparan sulfate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

NDST1: Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L- selectin ligands, thereby playing a role in inflammatory response. Belongs to the sulfotransferase 1 family. NDST subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transferase; Glycan Metabolism - heparan sulfate biosynthesis; Hydrolase; EC 2.8.2.8

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: Golgi membrane; integral to membrane

Molecular Function: deacetylase activity; [heparan sulfate]-glucosamine N-sulfotransferase activity

Biological Process: smoothened signaling pathway; fibroblast growth factor receptor signaling pathway; glycosaminoglycan metabolic process; MAPKKK cascade; pathogenesis; respiratory gaseous exchange; embryonic viscerocranium morphogenesis; polysaccharide biosynthetic process; glycosaminoglycan biosynthetic process; heparin biosynthetic process; forebrain development; midbrain development; heparan sulfate proteoglycan biosynthetic process; carbohydrate metabolic process; embryonic neurocranium morphogenesis; inflammatory response

Disease: Mental Retardation, Autosomal Recessive 46