FYVE, Rhogef and Ph Domain Containing 2 (FGD2) Antibody – Rabbit Polyclonal

FGD2: an endosome and ruffle membrane-associated guanine nucleotide exchange factor (GEF) that activates CDC42, a small G protein of the Rho-subfamily. Interacts with RAB6A bound to GTP. Activates JNK1 via CDC42 but not RAC1. Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate. The FYVE-type zinc-finger is necessary for early endosome localization. Recruitment to endosomal membranes via this domain requires the presence of phosphatidylinositol 3-phosphate or other phosphatidylinositides. The PH domain is necessary for localization to the ruffle membrane. Recruitment to ruffle membrane occurs through binding of phosphoinositides by the PH domain. This domain also contributes to the lipid-binding properties of the protein. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs, Rac/Rho; GEFs

Chromosomal Location of Human Ortholog: 6p21.2

Cellular Component: ruffle; Golgi apparatus; cytoskeleton; early endosome membrane; lamellipodium; cytoplasm; nucleus; cytosol

Molecular Function: small GTPase binding; Rho guanyl-nucleotide exchange factor activity; metal ion binding; guanyl-nucleotide exchange factor activity

Biological Process: regulation of cell shape; regulation of small GTPase mediated signal transduction; filopodium formation; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; cytoskeleton organization and biogenesis; actin cytoskeleton organization and biogenesis; positive regulation of GTPase activity