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CXXC Finger 1 (PHD Domain) (CXXC1) Antibody – Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS710810

MBS710810 is an antibody targeting CXXC1. Also known as Rabbit anti-human CXXC finger 1 (PHD domain) polyclonal Antibody. Reactive in Human, Mouse, Rat. More details

$590 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CXXC finger 1 (PHD domain) (CXXC1), Polyclonal Antibody
Full Product Name
Rabbit anti-human CXXC finger 1 (PHD domain) polyclonal Antibody
Product Gene Name
anti-CXXC1 antibody
Clonality
Polyclonal
Isotype
IgG
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Molecular Weight
76,227 Da
OMIM
609150
Immunogen
Human CXXC1
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-12336 / sc-12339 / sc-25391
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CXXC1 antibody
ELISA (EIA)

Other Notes

Small volumes of anti-CXXC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CXXC1. It may not necessarily be applicable to this product.

NCBI GI #
119583373
NCBI GeneID
30827
NCBI Accession #
EAW62969.1
UniProt Secondary Accession #
Q8N2W4; Q96BC8; Q9P2V7; B2RC03
UniProt Related Accession #
Q9P0U4
NCBI Official Full Name
CXXC finger 1 (PHD domain), isoform CRA_b
NCBI Official Synonym Full Names
CXXC finger protein 1
NCBI Official Symbol
CXXC1
NCBI Official Synonym Symbols
CFP1; CGBP; SPP1; PCCX1; PHF18; hCGBP; ZCGPC1; HsT2645; 2410002I16Rik; 5830420C16Rik
UniProt Protein Name
CXXC-type zinc finger protein 1
UniProt Synonym Protein Names
CpG-binding protein; PHD finger and CXXC domain-containing protein 1
Protein Family
CXXC-type zinc finger protein
UniProt Gene Name
CXXC1
UniProt Synonym Gene Names
CFP1; CGBP; PCCX1; PHF18
UniProt Entry Name
CXXC1_HUMAN
NCBI Protein Information
CXXC-type zinc finger protein 1; CpG binding protein; cpG-binding protein; CXXC finger 1 (PHD domain); zinc finger, CpG binding-type containing 1; PHD finger and CXXC domain-containing protein 1; DNA-binding protein with PHD finger and CXXC domain

NCBI Summary for CXXC1

Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression (Carlone and Skalnik, 2001 [PubMed 11604496]).[supplied by OMIM, Mar 2008]

UniProt Comments for CXXC1

CXXC1: Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 18q12

Cellular Component: nucleoplasm; histone methyltransferase complex; nuclear matrix; cytoplasm; nuclear speck; nucleus

Molecular Function: protein binding; zinc ion binding; unmethylated CpG binding; histone lysine N-methyltransferase activity (H3-K4 specific)

Biological Process: cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; transcription, DNA-dependent; regulation of transcription, DNA-dependent; unfolded protein response; positive regulation of transcription, DNA-dependent; histone H3-K4 methylation
Show more

Research Articles on CXXC1

1. NF-kappaB recruitment enhanced the occupancy of the CpG island within the 14-3-3gamma promoter by CFP1.14-3-3gamma induction in CSR is enabled by the CFP1-mediated H3K4me3 enrichment in the promoter, dependent on NF-kappaB and sustained by E2A.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CXXC1 antibody

 Reference Product  PubMed Publications
 SETD1A antibody  >5 publications with CXXC1 and SETD1A
 SETD1B antibody  >3 publications with CXXC1 and SETD1B
 MECP2 antibody  >1 publications with CXXC1 and MECP2

Pathways associated with anti-CXXC1 antibody

 Products by Pathway  Pathway Diagram
 IRE1alpha Activates Chaperones Pathway antibodies  IRE1alpha Activates Chaperones Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Unfolded Protein Response (UPR) Pathway antibodies  Unfolded Protein Response (UPR) Pathway Diagram
 XBP1(S) Activates Chaperone Genes Pathway antibodies  XBP1(S) Activates Chaperone Genes Pathway Diagram

Diseases associated with anti-CXXC1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >2 publications with CXXC1 and Breast Neoplasms
 Hypertension Antibodies  >1 publications with CXXC1 and Hypertension
 Liver Diseases Antibodies  >1 publications with CXXC1 and Liver Diseases
 Cardiovascular Diseases Antibodies  >1 publications with CXXC1 and Cardiovascular Diseases
 Embryo Loss Antibodies  >1 publications with CXXC1 and Embryo Loss
 Immune System Diseases Antibodies  >1 publications with CXXC1 and Immune System Diseases

Organs/Tissues associated with anti-CXXC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with CXXC1 and Blood
 Kidney Antibodies  >2 publications with CXXC1 and Kidney
 Brain Antibodies  >2 publications with CXXC1 and Brain
 Nerve Antibodies  >1 publications with CXXC1 and Nerve
 Liver Antibodies  >1 publications with CXXC1 and Liver
 Mammary Gland Antibodies  >1 publications with CXXC1 and Mammary Gland
 Placenta Antibodies  >1 publications with CXXC1 and Placenta
 Lymph Node Antibodies  >1 publications with CXXC1 and Lymph Node
 Embryonic Tissue Antibodies  >1 publications with CXXC1 and Embryonic Tissue
 Testis Antibodies  >1 publications with CXXC1 and Testis
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