Mitogen-Activated Protein Kinase 8 Interacting Protein 2 (MAPK8IP2) Antibody – Rabbit Polyclonal

The protein encoded by this gene is closely related to MAPK8IP1/IB1/JIP-1, a scaffold protein that is involved in the c-Jun amino-terminal kinase signaling pathway. This protein is expressed in brain and pancreatic cells. It has been shown to interact with, and regulate the activity of MAPK8/JNK1, and MAP2K7/MKK7 kinases. This protein thus is thought to function as a regulator of signal transduction by protein kinase cascade in brain and pancreatic beta-cells. [provided by RefSeq, Feb 2014]

MAPK8IP2: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Belongs to the JIP scaffold family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, regulatory subunit; Activator

Chromosomal Location of Human Ortholog: 22q13.33

Cellular Component: protein complex; cell soma; cytoplasm

Molecular Function: protein binding; MAP-kinase scaffold activity; kinesin binding; beta-amyloid binding; protein complex binding; structural molecule activity; protein kinase binding; protein kinase activator activity

Biological Process: nonassociative learning; behavioral fear response; regulation of synaptic transmission, glutamatergic; dendrite morphogenesis; MAPKKK cascade; mating behavior; signal complex assembly; social behavior; regulation of JNK cascade; positive regulation of stress-activated MAPK cascade; positive regulation of protein kinase activity; JNK cascade; regulation of receptor activity; regulation of excitatory postsynaptic membrane potential