Polycystic Kidney Disease 2-Like 1 (PKD2L1) Antibody – Rabbit Polyclonal

This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

PKD2L1: May function as a subunit of an ion channel and act as a transducer of calcium-mediated signaling. Belongs to the polycystin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Motility/polarity/chemotaxis; Membrane protein, integral; Channel, cation

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: cell surface; membrane; intracellular membrane-bound organelle; endoplasmic reticulum; nonmotile primary cilium; integral to membrane; plasma membrane; receptor complex

Molecular Function: identical protein binding; sour taste receptor activity; protein binding; calcium-activated potassium channel activity; cation transmembrane transporter activity; calcium channel activity; cytoskeletal protein binding; cation channel activity; calcium ion binding; alpha-actinin binding; sodium channel activity; muscle alpha-actinin binding; calcium activated cation channel activity

Biological Process: smoothened signaling pathway; detection of mechanical stimulus; sensory perception of sour taste; detection of chemical stimulus involved in sensory perception of sour taste; cation transport