Nitrogen Fixation 1 Homolog (NFS1) Antibody – Rabbit Polyclonal

Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]

NFS1: Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Transferase; Mitochondrial; Cofactor and Vitamin Metabolism - thiamine; EC 2.8.1.7

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: nucleoplasm; mitochondrion; intracellular membrane-bound organelle; mitochondrial matrix; cytoplasm; nucleolus; cytosol; nucleus

Molecular Function: protein binding; protein homodimerization activity; cysteine desulfurase activity; pyridoxal phosphate binding

Biological Process: iron incorporation into metallo-sulfur cluster; cysteine metabolic process; vitamin metabolic process; sulfur amino acid metabolic process; protein complex assembly; Mo-molybdopterin cofactor biosynthetic process; molybdopterin cofactor biosynthetic process; water-soluble vitamin metabolic process