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DIX Domain Containing 1 (DIXDC1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS711137

MBS711137 is an antibody targeting DIXDC1. Also known as Rabbit anti-human DIX domain containing 1 polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$590 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DIX domain containing 1 (DIXDC1), Polyclonal Antibody
Full Product Name
Rabbit anti-human DIX domain containing 1 polyclonal Antibody
Product Gene Name
anti-DIXDC1 antibody
Product Synonym Names
DIX domain containing 1; DIXDC1; CCD1; KIAA1735
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Molecular Weight
24,313 Da
OMIM
610493
Immunogen
Human DIXDC1
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-109530 / sc-292126
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-DIXDC1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Other Notes

Small volumes of anti-DIXDC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DIXDC1. It may not necessarily be applicable to this product.

NCBI GI #
34190572
NCBI GeneID
85458
NCBI Accession #
AAH33034.1
UniProt Secondary Accession #
Q6P2J8; Q6PIK4; Q86SR7; Q8IVY4; Q96N69; Q9C0C8; A1A5D8; E9PRV4
UniProt Related Accession #
Q155Q3
NCBI Official Full Name
DIX domain containing 1
NCBI Official Synonym Full Names
DIX domain containing 1
NCBI Official Symbol
DIXDC1
NCBI Official Synonym Symbols
CCD1
UniProt Protein Name
Dixin
UniProt Synonym Protein Names
Coiled-coil protein DIX1; Coiled-coil-DIX1; DIX domain-containing protein 1
Protein Family
Dixin
UniProt Gene Name
DIXDC1
UniProt Synonym Gene Names
CCD1; KIAA1735; Coiled-coil-DIX1
UniProt Entry Name
DIXC1_HUMAN
NCBI Protein Information
dixin; coiled-coil protein DIX1

NCBI Summary for DIXDC1

The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

UniProt Comments for DIXDC1

DIXDC1: Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. Belongs to the DIXDC1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Cell adhesion

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: focal adhesion; protein complex; cell soma; nerve terminal; cytosol

Molecular Function: protein domain specific binding; gamma-tubulin binding; protein binding; mitogen-activated protein kinase kinase kinase binding; actin binding

Biological Process: cerebellar cortex development; negative regulation of neuron differentiation; Wnt receptor signaling pathway; regulation of actin cytoskeleton organization and biogenesis; positive regulation of JNK cascade; cerebral cortex radially oriented cell migration; positive regulation of axonogenesis; cell cycle; forebrain ventricular zone progenitor cell division
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Research Articles on DIXDC1

1. DIXDC1 depletion results in upregulation of Snail1 in a FAK-dependent manner, leading to increased cell invasion. MARK1 phosphorylation of DIXDC1 is required for its localization to focal adhesions and ability to suppress metastasis in mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DIXDC1 antibody

 Reference Product  PubMed Publications
 NDEL1 antibody  >2 publications with DIXDC1 and NDEL1
 DVL2 antibody  >2 publications with DIXDC1 and DVL2
 MAP3K1 antibody  >1 publications with DIXDC1 and MAP3K1
 DLAT antibody  >1 publications with DIXDC1 and DLAT
 MAP3K4 antibody  >1 publications with DIXDC1 and MAP3K4

Diseases associated with anti-DIXDC1 antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >1 publications with DIXDC1 and Mental Disorders

Organs/Tissues associated with anti-DIXDC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with DIXDC1 and Brain
 Lung Antibodies  >3 publications with DIXDC1 and Lung
 Muscle Antibodies  >1 publications with DIXDC1 and Muscle
 Stomach Antibodies  >1 publications with DIXDC1 and Stomach
 Uncharacterized Tissue Antibodies  >1 publications with DIXDC1 and Uncharacterized Tissue
 Bone Antibodies  >1 publications with DIXDC1 and Bone
 Kidney Antibodies  >1 publications with DIXDC1 and Kidney
 Embryonic Tissue Antibodies  >1 publications with DIXDC1 and Embryonic Tissue
 Intestine Antibodies  >1 publications with DIXDC1 and Intestine
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