Deleted in Liver Cancer 1 (DLC1) Antibody – Rabbit Polyclonal

This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]

DLC1: Functions as a GTPase-activating protein specific for Rho and an activator of PLCD1 in vivo and induces morphological changes and detachment through cytoskeletal reorganization. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; GAPs, Rac/Rho; Tumor suppressor

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: cortical actin cytoskeleton; focal adhesion; cytoplasm; caveola; nucleus; cytosol

Molecular Function: protein binding; SH2 domain binding; lipid binding

Biological Process: focal adhesion formation; caspase activation; heart morphogenesis; hindbrain morphogenesis; negative regulation of stress fiber formation; apoptosis; negative regulation of focal adhesion formation; positive regulation of protein amino acid dephosphorylation; regulation of cell shape; negative regulation of cell proliferation; regulation of small GTPase mediated signal transduction; negative regulation of Rho protein signal transduction; regulation of actin cytoskeleton organization and biogenesis; small GTPase mediated signal transduction; neural tube closure; forebrain development; actin cytoskeleton organization and biogenesis; negative regulation of cell migration

Disease: Colorectal Cancer