UDP-Glucose Pyrophosphorylase 2 (UGP2) Antibody – Rabbit Polyclonal

The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UGP2: Plays a central role as a glucosyl donor in cellular metabolic pathways. Belongs to the UDPGP type 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.7.9; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Transferase; Carbohydrate Metabolism - galactose

Chromosomal Location of Human Ortholog: 2p14-p13

Cellular Component: nucleus; cytosol

Molecular Function: pyrimidine ribonucleotide binding; protein binding; UTP:glucose-1-phosphate uridylyltransferase activity; metal ion binding; glucose binding

Biological Process: glycogen biosynthetic process; xenobiotic metabolic process; carbohydrate metabolic process; glucose metabolic process; pathogenesis; glucose 1-phosphate metabolic process; UDP-glucuronate biosynthetic process; UDP-glucose metabolic process