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Ubiquitin Carboxyl-Terminal Hydrolase L5 (UCHL5) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS711453

MBS711453 is an antibody targeting UCHL5. Also known as Rabbit anti-human ubiquitin carboxyl-terminal hydrolase L5 polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$590 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ubiquitin carboxyl-terminal hydrolase L5 (UCHL5), Polyclonal Antibody
Full Product Name
Rabbit anti-human ubiquitin carboxyl-terminal hydrolase L5 polyclonal Antibody
Product Gene Name
anti-UCHL5 antibody
Product Synonym Names
ubiquitin carboxyl-terminal hydrolase L5; UCHL5; CGI-70; INO80R; UCH37
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Molecular Weight
37,353 Da
OMIM
610667
Immunogen
Human UCHL5
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-83058 / sc-98673
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-UCHL5 antibody
ELISA (EIA), Immunohistochemistry (IHC)

Other Notes

Small volumes of anti-UCHL5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for UCHL5. It may not necessarily be applicable to this product.

NCBI GI #
15930175
NCBI GeneID
51377
NCBI Accession #
AAH15521.1
UniProt Secondary Accession #
Q5LJA6; Q5LJA7; Q8TBS4; Q96BJ9; Q9H1W5; Q9P0I3; Q9UQN2
UniProt Related Accession #
Q9Y5K5
NCBI Official Full Name
Ubiquitin carboxyl-terminal hydrolase L5
NCBI Official Synonym Full Names
ubiquitin carboxyl-terminal hydrolase L5
NCBI Official Symbol
UCHL5
NCBI Official Synonym Symbols
UCH37; CGI-70; INO80R; UCH-L5
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase isozyme L5
UniProt Synonym Protein Names
Ubiquitin C-terminal hydrolase UCH37; Ubiquitin thioesterase L5
Protein Family
Ubiquitin carboxyl-terminal hydrolase
UniProt Gene Name
UCHL5
UniProt Synonym Gene Names
UCH37; UCH-L5
UniProt Entry Name
UCHL5_HUMAN
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase isozyme L5; INO80 complex subunit R; ubiquitin thioesterase L5; ubiquitin C-terminal hydrolase UCH37; ubiquitin carboxyl-terminal esterase L5

UniProt Comments for UCHL5

UCHL5: Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. Belongs to the peptidase C12 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin-specific protease; EC 3.4.19.12; Ubiquitin conjugating system; Protease

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: proteasome complex; cytosol; nucleus

Molecular Function: omega peptidase activity; protein binding; ubiquitin-specific protease activity; endopeptidase inhibitor activity

Biological Process: ubiquitin-dependent protein catabolic process; protein deubiquitination; regulation of transcription, DNA-dependent; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; midbrain development; negative regulation of transforming growth factor beta receptor signaling pathway; forebrain morphogenesis; DNA repair; lateral ventricle development; DNA recombination
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Research Articles on UCHL5

1. b-AP15 is an inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UCHL5 antibody

 Reference Product  PubMed Publications
 ADRM1 antibody  >8 publications with UCHL5 and ADRM1

Pathways associated with anti-UCHL5 antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downregulation Of TGF-beta Receptor Signaling Pathway antibodies  Downregulation Of TGF-beta Receptor Signaling Pathway Diagram
 Loss Of Function Of SMAD2/3 In Cancer Pathway antibodies  Loss Of Function Of SMAD2/3 In Cancer Pathway Diagram
 Loss Of Function Of SMAD4 In Cancer Pathway antibodies  Loss Of Function Of SMAD4 In Cancer Pathway Diagram
 Loss Of Function Of TGFBR1 In Cancer Pathway antibodies  Loss Of Function Of TGFBR1 In Cancer Pathway Diagram
 Loss Of Function Of TGFBR2 In Cancer Pathway antibodies  Loss Of Function Of TGFBR2 In Cancer Pathway Diagram
 SMAD2/3 MH2 Domain Mutants In Cancer Pathway antibodies  SMAD2/3 MH2 Domain Mutants In Cancer Pathway Diagram
 SMAD2/3 Phosphorylation Motif Mutants In Cancer Pathway antibodies  SMAD2/3 Phosphorylation Motif Mutants In Cancer Pathway Diagram
 SMAD4 MH2 Domain Mutants In Cancer Pathway antibodies  SMAD4 MH2 Domain Mutants In Cancer Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram

Diseases associated with anti-UCHL5 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >3 publications with UCHL5 and Adenocarcinoma
 Liver Diseases Antibodies  >3 publications with UCHL5 and Liver Diseases
 Breast Neoplasms Antibodies  >2 publications with UCHL5 and Breast Neoplasms
 Carcinoma, Squamous Cell Antibodies  >2 publications with UCHL5 and Carcinoma, Squamous Cell
 Carcinoma, Hepatocellular Antibodies  >2 publications with UCHL5 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >2 publications with UCHL5 and Inflammation
 Neoplasm Metastasis Antibodies  >2 publications with UCHL5 and Neoplasm Metastasis
 Cell Transformation, Neoplastic Antibodies  >1 publications with UCHL5 and Cell Transformation, Neoplastic
 Anemia Antibodies  >1 publications with UCHL5 and Anemia
 Nervous System Diseases Antibodies  >1 publications with UCHL5 and Nervous System Diseases

Organs/Tissues associated with anti-UCHL5 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >3 publications with UCHL5 and Liver
 Kidney Antibodies  >2 publications with UCHL5 and Kidney
 Blood Antibodies  >2 publications with UCHL5 and Blood
 Uterus Antibodies  >1 publications with UCHL5 and Uterus
 Lung Antibodies  >1 publications with UCHL5 and Lung
 Skin Antibodies  >1 publications with UCHL5 and Skin
 Bone Antibodies  >1 publications with UCHL5 and Bone
 Spleen Antibodies  >1 publications with UCHL5 and Spleen
 Intestine Antibodies  >1 publications with UCHL5 and Intestine
 Lymph Antibodies  >1 publications with UCHL5 and Lymph
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