STT3, Subunit of the Oligosaccharyltransferase Complex, Homolog B (STT3B) Antibody – Rabbit Polyclonal

STT3B: Catalytic component of oligosaccharyltransferase (OST) oligosaccharyltransferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X- Ser/Thr consensus motif in nascent polypeptide chains. N- glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient cotranslational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N- glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation. Belongs to the STT3 family.

Protein type: Glycan Metabolism - N-glycan biosynthesis; EC 2.4.99.18; Membrane protein, integral; Membrane protein, multi-pass; Transferase

Chromosomal Location of Human Ortholog: 3p23

Cellular Component: membrane; endoplasmic reticulum; oligosaccharyl transferase complex; integral to membrane

Molecular Function: dolichyl-diphosphooligosaccharide-protein glycotransferase activity

Biological Process: ER-associated protein catabolic process; co-translational protein modification; protein amino acid N-linked glycosylation via asparagine; glycoprotein catabolic process; post-translational protein modification; response to unfolded protein

Disease: Congenital Disorder Of Glycosylation, Type Ix