Angiotensin II Receptor-Associated Protein (AGTRAP) Antibody – Rabbit Polyclonal

This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

AGTRAP: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Endoplasmic reticulum; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: nucleoplasm; Golgi membrane; endoplasmic reticulum membrane; cytoplasmic vesicle membrane; intracellular membrane-bound organelle; cytoplasm; plasma membrane; integral to membrane; cell cortex

Molecular Function: protein binding; angiotensin type II receptor activity

Biological Process: regulation of blood pressure; response to hypoxia