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Lysophosphatidylcholine Acyltransferase 1 (LPCAT1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS711659

Rabbit polyclonal to LPCAT1 Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for… More details

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Product Overview

Online Datasheet in PDF
Product Name
lysophosphatidylcholine acyltransferase 1 (LPCAT1), Polyclonal Antibody
Full Product Name
Rabbit anti-human lysophosphatidylcholine acyltransferase 1 polyclonal Antibody
Product Gene Name
anti-LPCAT1 antibody
Product Synonym Names
lysophosphatidylcholine acyltransferase 1; LPCAT1; AYTL2; FLJ12443; FLJ41609; PFAAP3; lpcat
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human,Mouse,Rat; Other species are not tested. Please decide the specificity by homology.
Form/Format
Liquid
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C Upon delivery aliquot and store at -20 degree C or -80 degreeC. Avoid repeated freeze.
OMIM
610472
Immunogen
Human LPCAT1
Conjugate
Non-conjugated
Storage Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-LPCAT1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-LPCAT1 antibody
ELISA:Use at an assay dependent dilution.
WB : 1:1000-1:10000
IP : 1:1000-1:10000
IHC : 1:20-1:200
IF : 1:10-1:100(Recommender dilutions)

Positive WB detected in: Human lung tissue, mouse brain tissue, mouse lung tissue, mouse spleen tissue, rat brain tissue, rat lung tissue.
Positive IP detected in: Mouse brain tissue
Positive IHC detected in: Human colon cancer tissue, human lung cancer tissue
Positive IF detected in: MCF-7 cells

Other Notes

Small volumes of anti-LPCAT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LPCAT1 purchase

MBS711659 is an antibody targeting LPCAT1. Also known as Rabbit anti-human lysophosphatidylcholine acyltransferase 1 polyclonal Antibody. Reactive in Human,Mouse,Rat; Other species are not tested. Please decide the specificity by homology.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LPCAT1. It may not necessarily be applicable to this product.

NCBI GI #
33946291
NCBI GeneID
79888
NCBI Accession #
NP_079106.3
UniProt Secondary Accession #
Q1HAQ1; Q7Z4G6; Q8N3U7; Q8WUL8; Q9GZW6
UniProt Related Accession #
Q8NF37
GenBank Nucleotide #
NM_024830.3
NCBI Official Full Name
lysophosphatidylcholine acyltransferase 1
NCBI Official Synonym Full Names
lysophosphatidylcholine acyltransferase 1
NCBI Official Symbol
LPCAT1
NCBI Official Synonym Symbols
AYTL2; lpcat; PFAAP3
UniProt Protein Name
Lysophosphatidylcholine acyltransferase 1
UniProt Synonym Protein Names
1-acylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67); Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Acetyl-CoA:lyso-PAF acetyltransferase; Lyso-PAF acetyltransferase; LysoPAFAT; Acyltransferase-like 2; Phosphonoformate immuno-associated protein 3
Protein Family
Lysophosphatidylcholine acyltransferase
UniProt Gene Name
LPCAT1
UniProt Synonym Gene Names
AYTL2; PFAAP3; LPC acyltransferase 1; LPCAT-1; LysoPC acyltransferase 1; Acetyl-CoA:lyso-PAF acetyltransferase; Lyso-PAF acetyltransferase; LysoPAFAT
UniProt Entry Name
PCAT1_HUMAN
NCBI Protein Information
lysophosphatidylcholine acyltransferase 1; LPCAT-1; lysoPAFAT; LPC acyltransferase 1; acyltransferase like 2; acyltransferase-like 2; lysoPC acyltransferase 1; lyso-PAF acetyltransferase; regulated by phosphonoformate; acetyl-CoA:lyso-PAF acetyltransferase; phosphonoformate immuno-associated protein 3; 1-acylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; acyl-CoA:lysophosphatidylcholine acyltransferase 1; acetyl-CoA:lyso-platelet-activating factor acetyltransferase

NCBI Summary for LPCAT1

Lysophosphatidylcholine (LPC) acyltransferase (LPCAT; EC 2.3.1.23) catalyzes the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis (Nakanishi et al., 2006 [PubMed 16704971]).[supplied by OMIM, May 2008]

UniProt Comments for LPCAT1

LPCAT1: Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Protein type: Membrane protein, integral; EC 2.3.1.23; EC 2.3.1.67; Acetyltransferase; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 5p15.33

Cellular Component: Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane; lipid particle

Molecular Function: 1-alkylglycerophosphocholine O-acetyltransferase activity; 1-alkenylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphocholine O-acyltransferase activity; 1-alkylglycerophosphocholine O-acyltransferase activity; calcium ion binding

Biological Process: retina development in camera-type eye; phospholipid metabolic process; glycerophospholipid biosynthetic process; positive regulation of protein catabolic process; phosphatidic acid biosynthetic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; surfactant homeostasis; phospholipid biosynthetic process
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Research Articles on LPCAT1

1. The prognostic impact of LPCAT1 expression was independent of histological and clinical parameters. It is concluded, that LPCAT1 measurement, either alone or in combination, may be utilized for better clinical decision-making.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LPCAT1 antibody

 Reference Product  PubMed Publications
 CHPT1 antibody  >2 publications with LPCAT1 and CHPT1
 PLA2G4A antibody  >2 publications with LPCAT1 and PLA2G4A

Pathways associated with anti-LPCAT1 antibody

 Products by Pathway  Pathway Diagram
 Acyl Chain Remodelling Of PC Pathway antibodies  Acyl Chain Remodelling Of PC Pathway Diagram
 Acyl Chain Remodelling Of PG Pathway antibodies  Acyl Chain Remodelling Of PG Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Glycerophospholipid Biosynthesis Pathway antibodies  Glycerophospholipid Biosynthesis Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram

Diseases associated with anti-LPCAT1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7 publications with LPCAT1 and Inflammation
 Disease Models, Animal Antibodies  >5 publications with LPCAT1 and Disease Models, Animal
 Fatty Liver Antibodies  >3 publications with LPCAT1 and Fatty Liver
 Liver Diseases Antibodies  >2 publications with LPCAT1 and Liver Diseases
 Nervous System Diseases Antibodies  >2 publications with LPCAT1 and Nervous System Diseases
 Lung Neoplasms Antibodies  >1 publications with LPCAT1 and Lung Neoplasms
 Spinal Cord Diseases Antibodies  >1 publications with LPCAT1 and Spinal Cord Diseases
 Fibrosis Antibodies  >1 publications with LPCAT1 and Fibrosis
 Neoplasm Metastasis Antibodies  >1 publications with LPCAT1 and Neoplasm Metastasis
 Carcinoma, Hepatocellular Antibodies  >1 publications with LPCAT1 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-LPCAT1 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >15 publications with LPCAT1 and Lung
 Blood Antibodies  >4 publications with LPCAT1 and Blood
 Liver Antibodies  >4 publications with LPCAT1 and Liver
 Eye Antibodies  >3 publications with LPCAT1 and Eye
 Prostate Antibodies  >3 publications with LPCAT1 and Prostate
 Ovary Antibodies  >2 publications with LPCAT1 and Ovary
 Nerve Antibodies  >1 publications with LPCAT1 and Nerve
 Heart Antibodies  >1 publications with LPCAT1 and Heart
 Kidney Antibodies  >1 publications with LPCAT1 and Kidney
 Brain Antibodies  >1 publications with LPCAT1 and Brain
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