NCK-Associated Protein 1-Like (NCKAP1L) Antibody – Polyclonal

This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]

HEM1: a component of the Scar/WAVE complex that plays an important role in regulating cell shape and motility. Found at elevated levels in cells of hematopoietic lineage. Localizes to propagating waves at the leading edge of a motile human neutrophils. The complex stimulates actin assembly; polymerized actin is reciprocally required to remove the complex from the membrane. Overexpression is associated with poor outcome in B-cell chronic lymphocytic leukemia patients.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q13.1

Cellular Component: membrane; integral to plasma membrane; cytosol

Molecular Function: protein binding; protein complex binding; protein kinase activator activity

Biological Process: response to drug; neutrophil chemotaxis; erythrocyte development; positive regulation of erythrocyte differentiation; myeloid cell homeostasis; positive regulation of cell adhesion mediated by integrin; positive regulation of CD4-positive, alpha beta T cell differentiation; chemotaxis; maintenance of cell polarity; positive regulation of CD8-positive, alpha-beta T cell differentiation; positive regulation of lymphocyte differentiation; B cell receptor signaling pathway; negative regulation of interleukin-17 production; positive regulation of actin filament polymerization; B cell homeostasis; positive regulation of protein kinase activity; positive regulation of B cell proliferation; negative regulation of interleukin-6 production; positive regulation of B cell differentiation; positive regulation of T cell proliferation; protein complex assembly; T cell homeostasis; cortical actin cytoskeleton organization and biogenesis; positive regulation of gamma-delta T cell differentiation; positive regulation of phagocytosis, engulfment; positive regulation of phosphorylation; negative regulation of apoptosis