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Membrane-Associated Ring Finger (C3HC4) 5 (MARCH5) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS711897

MBS711897 is an antibody targeting MARCH5. Also known as MARCH5 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$590 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
membrane-associated ring finger (C3HC4) 5 (MARCH5), Polyclonal Antibody
Full Product Name
MARCH5 Antibody
Product Gene Name
anti-MARCH5 antibody
Product Synonym Names
membrane-associated ring finger (C3HC4) 5; MARCH5; FLJ20445; MARCH-V; MITOL; RNF153
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
OMIM
610637
Immunogen
Human MARCH5
Species
Homo sapiens (Human)
Target Names
MARCH5
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-109542 / sc-109543
Product Type
Purified rabbit Anti human PolyClonal Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MARCH5 antibody
ELISA (EIA), Western Blot (WB)

Other Notes

Small volumes of anti-MARCH5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MARCH5. It may not necessarily be applicable to this product.

NCBI GI #
15930072
NCBI GeneID
54708
NCBI Accession #
AAH15480.1
UniProt Related Accession #
Q9NX47
NCBI Official Full Name
Membrane-associated ring finger (C3HC4) 5
NCBI Official Synonym Full Names
membrane-associated ring finger (C3HC4) 5
NCBI Official Symbol
MARCH5
NCBI Official Synonym Symbols
MITOL; RNF153; MARCH-V
UniProt Protein Name
E3 ubiquitin-protein ligase MARCH5
UniProt Synonym Protein Names
Membrane-associated RING finger protein 5; Membrane-associated RING-CH protein V; MARCH-V; Mitochondrial ubiquitin ligase; MITOL; RING finger protein 153
UniProt Gene Name
MARCH5
UniProt Synonym Gene Names
RNF153; MARCH-V; MITOL
UniProt Entry Name
MARH5_HUMAN
NCBI Protein Information
E3 ubiquitin-protein ligase MARCH5; ring finger protein 153; mitochondrial ubiquitin ligase; membrane-associated RING-CH protein V; membrane-associated RING finger protein 5

NCBI Summary for MARCH5

MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008]

UniProt Comments for MARCH5

MARCH5: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.

Protein type: Membrane protein, multi-pass; Ubiquitin conjugating system; Ligase; EC 6.3.2.19; Membrane protein, integral; EC 6.3.2.-; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 10q23.32-q23.33

Cellular Component: endoplasmic reticulum membrane; mitochondrial outer membrane; membrane; endoplasmic reticulum; integral to membrane

Molecular Function: GTPase binding; protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: protein autoubiquitination; protein polyubiquitination
Show more

Research Articles on MARCH5

1. MITOL regulates ER tethering to mitochondria by activating Mfn2 via K192 ubiquitination.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MARCH5 antibody

 Reference Product  PubMed Publications
 DNM1L antibody  >6 publications with MARCH5 and DNM1L
 MFN1 antibody  >5 publications with MARCH5 and MFN1
 MFN2 antibody  >3 publications with MARCH5 and MFN2
 FIS1 antibody  >1 publications with MARCH5 and FIS1
 MARCH2 antibody  >1 publications with MARCH5 and MARCH2

Organs/Tissues associated with anti-MARCH5 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >1 publications with MARCH5 and Prostate
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