Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNA3) Antibody – Rabbit

nAChRA3: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 3/CHRNA3 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, ligand-gated; Membrane protein, integral; Channel, cation; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; cell soma; dendrite; postsynaptic density; plasma membrane; integral to membrane; cell junction

Molecular Function: acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; acetylcholine binding; ligand-gated ion channel activity

Biological Process: regulation of smooth muscle contraction; nervous system development; transmembrane receptor protein tyrosine kinase activation (dimerization); regulation of acetylcholine secretion; regulation of dendrite morphogenesis; behavioral response to nicotine; locomotory behavior; signal transduction; synaptic transmission, cholinergic; synaptic transmission; regulation of membrane potential; ion transport; synaptic transmission involved in micturition; regulation of excitatory postsynaptic membrane potential

Disease: Smoking As A Quantitative Trait Locus 3