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PDZ Domain Containing 3 (PDZD3) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS712211

MBS712211 is an antibody targeting PDZD3. Also known as Rabbit anti-human PDZ domain containing 3 polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

$590 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PDZ domain containing 3 (PDZD3), Polyclonal Antibody
Full Product Name
Rabbit anti-human PDZ domain containing 3 polyclonal Antibody
Product Gene Name
Product Synonym Names
PDZ domain containing 3; PDZD3; FLJ22756; IKEPP; PDZK2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Molecular Weight
24,105 Da
OMIM
607146
Immunogen
Human PDZD3
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-82687 / sc-82689
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PDZD3 antibody
ELISA (EIA), Western Blot (WB)

Other Notes

Small volumes of anti-PDZD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PDZD3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
PDZ domain containing 3
NCBI Official Synonym Full Names
PDZ domain containing 3
NCBI Official Symbol
PDZD3
NCBI Official Synonym Symbols
IKEPP; PDZK2; NHERF4
UniProt Protein Name
Na(+)/H(+) exchange regulatory cofactor NHE-RF4
UniProt Synonym Protein Names
Intestinal and kidney-enriched PDZ protein; Natrium-phosphate cotransporter IIa C-terminal-associated protein 2; Na/Pi cotransporter C-terminal-associated protein 2; NaPi-Cap2; PDZ domain-containing protein 2; PDZ domain-containing protein 3; Sodium-hydrogen exchanger regulatory factor 4
UniProt Gene Name
PDZD3
UniProt Synonym Gene Names
IKEPP; NHERF4; PDZK2; NHERF-4; Na/Pi cotransporter C-terminal-associated protein 2; NaPi-Cap2
UniProt Entry Name
NHRF4_HUMAN
NCBI Protein Information
Na(+)/H(+) exchange regulatory cofactor NHE-RF4; Na(+)/H(+) exchange regulatory cofactor NHE-RF4; NHERF-4; naPi-Cap2; PDZ domain containing 2; PDZ domain-containing protein 2; PDZ domain-containing protein 3; intestinal and kidney enriched PDZ protein; intestinal and kidney-enriched PDZ protein; sodium-hydrogen exchanger regulatory factor 4; na/Pi cotransporter C-terminal-associated protein 2; natrium-phosphate cotransporter IIa C-terminal-associated protein 2

NCBI Summary for PDZD3

Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008]
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UniProt Comments for PDZD3

PDZD3: Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: apical part of cell; subapical complex; cytosol; brush border

Molecular Function: protein C-terminus binding; protein binding; guanylate cyclase inhibitor activity; ion channel inhibitor activity

Biological Process: cGMP-mediated signaling; response to toxin; negative regulation of guanylate cyclase activity; water transport; receptor guanylyl cyclase signaling pathway; ion transport; negative regulation of cGMP biosynthetic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-PDZD3 antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >1 publications with PDZD3 and Intestine
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